Alterbrassicicene A, a Highly Transformed Fusicoccane-Derived Diterpenoid with Potent PPAR-γ Agonistic Activity from Alternaria brassicicola

被引：38

作者：

Li, Fengli ^{[1
]}

Sun, Weiguang ^{[1
]}

Guan, Jiankun ^{[2
]}

Lu, Yuanyuan ^{[2
]}

Zhang, Sitian ^{[1
]}

Lin, Shuang ^{[1
]}

Liu, Junjun ^{[1
]}

Gao, Weixi ^{[1
]}

Wang, Jianping ^{[1
]}

Hu, Zhengxi ^{[1
]}

Zhang, Yonghui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 24期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

FUNGUS; THIAZOLIDINEDIONE; REVISIONS; LIGAND;

D O I：

10.1021/acs.orglett.8b03553

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alterbrassicicene A (1), a fusicoccane-derived diterpenoid with an unprecedented framework, together with two known biosynthetic intermediates (2 and 3), were characterized from Alternaria brassicicola. The absolute structure of 1 was assigned by extensive spectroscopic analyses and quantum chemical calculations. Compound 1 represents a newly transformed monocyclic carbon skeleton of a highly functionalized diterpenoid bearing unique dihydro-2(3H)-furanone and 2-cyclopenten1-one motifs. Compound 1 was the first fusicoccane-derived diterpenoid functioning as a potent PPAR-gamma agonist (EC50 = 744.1 nM).

引用

页码：7982 / 7986

页数：5

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