travelling salesman problem;
Euler tours;
DNA sequencing;
de Bruijn graphs;
approximation algorithms;
graph algorithms;
D O I:
10.1016/S0166-218X(98)00071-7
中图分类号:
O29 [应用数学];
学科分类号:
070104 ;
摘要:
In this paper we consider graph traversal problems (Euler and Travelling Salesman traversals) that arise from a particular technology for DNA sequencing - sequencing by hybridization (SBH). We first explain the connection of the graph problems to SBH and then focus on the traversal problems. We describe a practical polynomial time solution to the Travelling Salesman Problem in a rich class of directed graphs (including edge weighted binary de Bruijn graphs), and provide bounded-error approximation algorithms for the maximum weight TSP in a superset of those directed graphs. We also establish the existence of a matroid structure defined on the set of Euler and Hamilton paths in the restricted class of graphs. 1998 Published by Elsevier Science B.V. All rights reserved.