Rapid Assessment and Containment of Candida auris Transmission in Postacute Care Settings-Orange County, California, 2019

被引：21

作者：

Karmarkar, Ellora N. ^{[1
,2
]}

O'Donnell, Kathleen ^{[3
]}

Prestel, Christopher ^{[4
]}

Forsberg, Kaitlin ^{[5
]}

Gade, Lalitha ^{[6
]}

Jain, Seema ^{[7
]}

Schan, Douglas ^{[3
]}

Chow, Nancy ^{[6
]}

McDermott, Darby ^{[6
]}

Rossow, John ^{[4
]}

Toda, Mitsuru ^{[4
]}

Ruiz, Ryan ^{[8
]}

Hun, Sopheay ^{[8
]}

Dale, Jennifer L. ^{[9
]}

Gross, Annastasia ^{[9
]}

Maruca, Tyler ^{[10
]}

Glowicz, Janet ^{[6
]}

Brooks, Richard ^{[11
,12
]}

Bagheri, Hosniyeh ^{[7
]}

Nelson, Teresa ^{[7
]}

Gualandi, Nicole ^{[6
]}

Khwaja, Zenith ^{[7
]}

Horwich-Scholefield, Sam ^{[7
]}

Jacobs, Josh ^{[3
]}

Cheung, Michele ^{[3
]}

Walters, Maroya ^{[6
]}

Jacobs-Slifka, Kara ^{[6
]}

Stone, Nimalie D. ^{[6
]}

Mikhail, Lydia ^{[3
]}

Chaturvedi, Sudha ^{[13
]}

Klein, Liore ^{[10
]}

Vagnone, Paula Snippes ^{[9
]}

Schneider, Emily

Berkow, Elizabeth L. ^{[6
]}

Jackson, Brendan R. ^{[6
]}

Vallabhaneni, Snigdha ^{[6
]}

Zahn, Matthew ^{[3
]}

Epson, Erin ^{[7
,8
]}

机构：

[1] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Atlanta, GA USA

[2] Dept Publ Hlth, Atlanta, GA USA

[3] Orange Cty Hlth Care Agcy, Santa Ana, CA USA

[4] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Atlanta, GA USA

[5] Ctr Dis Control & Prevent & IHRC, Atlanta, GA USA

[6] Ctr Dis Control & Prevent, Atlanta, GA USA

[7] Calif Dept Publ Hlth, Richmond, CA USA

[8] Washington State Publ Hlth Labs, Shoreline, WA USA

[9] Minnesota Dept Hlth Publ Hlth Lab, St Paul, MN USA

[10] Maryland Dept Hlth, Labs Adm, Baltimore, MD USA

[11] Ctr Dis Control & Prevent, Atlanta, GA USA

[12] Maryland Dept Hlth, Infect Dis Epidemiol & Outbreak Response Bur, Baltimore, MD USA

[13] New York State Dept Hlth, Albany, NY 11101 USA

来源：

ANNALS OF INTERNAL MEDICINE | 2021年 / 174卷 / 11期

关键词：

NEW-YORK; RESISTANT; FACILITIES; OUTBREAK;

D O I：

10.7326/M21-2013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Candida auris, a multidrug-resistant yeast, can spread rapidly in ventilator-capable skilled-nursing facilities (vSNFs) and long-term acute care hospitals (LTACHs). In 2018, a laboratory serving LTACHs in southern California began identifying species of Candida that were detected in urine specimens to enhance surveillance of C auris, and C auris was identified in February 2019 in a patient in an Orange County (OC), California, LTACH. Further investigation identified C auris at 3 associated facilities. Objective: To assess the prevalence of C auris and infection prevention and control (IPC) practices in LTACHs and vSNFs in OC. Design: Point prevalence surveys (PPSs), postdischarge testing for C auris detection, and assessments of IPC were done from March to October 2019. Setting: All LTACHs (n = 3) and vSNFs (n = 14) serving adult patients in OC. Participants: Current or recent patients in LTACHs and vSNFs in OC. Intervention: In facilities where C auris was detected, PPSs were repeated every 2 weeks. Ongoing IPC support was provided. Measurements: Antifungal susceptibility testing and whole-genome sequencing to assess isolate relatedness. Results: Initial PPSs at 17 facilities identified 44 additional patients with C auris in 3 (100%) LTACHs and 6 (43%) vSNFs, with the first bloodstream infection reported in May 2019. By October 2019, a total of 182 patients with C auris were identified by serial PPSs and discharge testing. Of 81 isolates that were sequenced, all were clade III and highly related. Assessments of IPC identified gaps in hand hygiene, transmission-based precautions, and environmental cleaning. The outbreak was contained to 2 facilities by October 2019. Limitation: Acute care hospitals were not assessed, and IPC improvements over time could not be rigorously evaluated. Conclusion: Enhanced laboratory surveillance and prompt investigation with IPC support enabled swift identification and containment of C auris.

引用

页码：1554 / +

页数：10

共 36 条

[21] The Sequence Alignment/Map format and SAMtools
Li, Heng
Handsaker, Bob
Wysoker, Alec
Fennell, Tim
Ruan, Jue
Homer, Nils
Marth, Gabor
Abecasis, Goncalo
Durbin, Richard
[J]. BIOINFORMATICS, 2009, 25 (16) : 2078 - 2079
[22] Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses
Lockhart, Shawn R.
Etienne, Kizee A.
Vallabhaneni, Snigdha
Farooqi, Joveria
Chowdhary, Anuradha
Govender, Nelesh P.
Colombo, Arnaldo Lopes
Calvo, Belinda
Cuomo, Christina A.
Desjardins, Christopher A.
Berkow, Elizabeth L.
Castanheira, Mariana
Magobo, Rindidzani E.
Jabeen, Kauser
Asghar, Rana J.
Meis, Jacques F.
Jackson, Brendan
Chiller, Tom
Litvintseva, Anastasia P.
[J]. CLINICAL INFECTIOUS DISEASES, 2017, 64 (02) : 134 - 140
[23] Lyman M, 2021, MMWR-MORBID MORTAL W, V70, P1022, DOI 10.15585/mmwr.mm7029a2
[24] COVID-19 in a Long-Term Care Facility - King County, Washington, February 27-March 9, 2020
McMichael, Temet M.
Clark, Shauna
Pogosjans, Sargis
Kay, Meagan
Lewis, James
Baer, Atar
Kawakami, Vance
Lukoff, Margaret D.
Ferro, Jessica
Brostrom-Smith, Claire
Riedo, Francis X.
Russell, Denny
Hiatt, Brian
Montgomery, Patricia
Rao, Agam K.
Currie, Dustin W.
Chow, Eric J.
Tobolowsky, Farrell
Bardossy, Ana C.
Oakley, Lisa P.
Jacobs, Jesica R.
Schwartz, Noah G.
Stone, Nimalie
Reddy, Sujan C.
Jernigan, John A.
Honein, Margaret A.
Clark, Thomas A.
Duchin, Jeffrey S.
[J]. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2020, 69 (12): : 339 - 342
[25] Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species
Munoz, Jose F.
Gade, Lalitha
Chow, Nancy A.
Loparev, Vladimir N.
Juieng, Phalasy
Berkow, Elizabeth L.
Farrer, Rhys A.
Litvintseva, Anastasia P.
Cuomo, Christina A.
[J]. NATURE COMMUNICATIONS, 2018, 9
[26] Long-Term Acute Care Hospitals
Munoz-Price, L. Silvia
[J]. CLINICAL INFECTIOUS DISEASES, 2009, 49 (03) : 438 - 443
[27] Ostrowsky B, 2020, MMWR-MORBID MORTAL W, V69, P6, DOI 10.15585/mmwr.mm6901a2
[28] Regional Emergence of Candida auris in Chicago and Lessons Learned From Intensive Follow-up at 1 Ventilator-Capable Skilled Nursing Facility
Pacilli, Massimo
Kerins, Janna L.
Clegg, Whitney J.
Walblay, Kelly A.
Adil, Hira
Kemble, Sarah K.
Xydis, Shannon
McPherson, Tristan D.
Lin, Michael Y.
Hayden, Mary K.
Froilan, Mary Carl
Soda, Elizabeth
Tang, Angela S.
Valley, Ann
Forsberg, Kaitlin
Gable, Paige
Moulton-Meissner, Heather
Sexton, D. Joseph
Slifka, Kara M. Jacobs
Vallabhaneni, Snigdha
Walters, Maroya Spalding
Black, Stephanie R.
[J]. CLINICAL INFECTIOUS DISEASES, 2020, 71 (11) : E718 - E725
[29] Prestel C, 2021, MMWR-MORBID MORTAL W, V70, P56, DOI 10.15585/mmwr.mm7002e3
[30] Price TK, EMERGENCE CLADE 3 CA, DOI 10/1101/2020.10.26.20214908

← 1 2 3 4 →