Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF-β1 signaling in articular cartilage in a rodent osteoarthritis model

被引：8

作者：

Mu, Wenbo ^{[1
]}

Xu, Boyong ^{[1
]}

Ma, Hairong ^{[1
,2
]}

Ji, Baochao ^{[1
]}

Zhang, Zhendong ^{[1
]}

Li, Jiao ^{[1
]}

Amat, Abdusami ^{[1
]}

Cao, Li ^{[1
]}

机构：

[1] Xinjiang Med Univ, Affiliated Hosp 1, Dept Orthopaed, 137 South Liyushan Rd, Urumqi 830054, Xinjiang, Peoples R China

[2] Xinjiang Med Univ, Affiliated Hosp 1, Clin Med Res Inst, Urumqi 830054, Xinjiang, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2017年 / 16卷 / 05期

基金：

中国国家自然科学基金;

关键词：

osteoarthritis; articular artilage; TGF-beta; 1; elevation; halofuginone; GROWTH-FACTOR-BETA; VERSUS-HOST-DISEASE; GENE-EXPRESSION; UP-REGULATION; CHONDROCYTES; FIBROSIS; BONE; DIFFERENTIATION; PATHOGENESIS; INFLAMMATION;

D O I：

10.3892/mmr.2017.7549

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osteoarthritis (OA) is the most common degenerative condition of the weight-bearing joints worldwide without effective medical therapy. In order to investigate whether administration of halofuginone (HF) may attenuate OA, the present study allocated 3-month-old male mice into Sham group, vehicle-treated anterior cruciate ligament transection (ACLT) group and HF-treated ACLT group. The present study determined that HF treatment reduced the expression of matrix metallopeptidase-13 and collagen X in articular cartilage. Additionally, it lowered the Osteoarthritis Research Society International-Modified Mankin score and prevented the loss of articular cartilage from Safranin O and Fast Green staining. HF reduced the progression of osteoarthritis by downregulating abnormally elevated TGF-beta 1 activity in articular cartilage. Administration of HF may be a potential preventive therapy for OA.

引用

页码：7679 / 7684

页数：6

共 36 条

[1] TGF-BETA-1 PREVENTS HYPERTROPHY OF EPIPHYSEAL CHONDROCYTES - REGULATION OF GENE-EXPRESSION FOR CARTILAGE MATRIX PROTEINS AND METALLOPROTEASES [J].