Cardioprotective effects of omega 3 fatty acids: origin of the variability

被引：12
作者：
Roy, Jerome [1 ]
Le Guennec, Jean-Yves [1 ,2 ]
机构：
[1] Univ Montpellier, CNRS, UMR 9214, Inserm,U1046,PHYMEDEX, Montpellier, France
[2] CHU Arnaud de Villeneuve, CNRS, UMR 9214, Inserm 1046,Physiol & Med Expt Coeur & Muscle, Batiment Crastes Paulet 371 Ave Doyen Gaston, F-34295 Montpellier 5, France
来源：
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY | 2017年 / 38卷 / 01期
关键词：
omega-3; PUFA; Sarcomere proteins; Cardiac arrhythmias; Controversies; POLYUNSATURATED FATTY-ACIDS; CORONARY-HEART-DISEASE; RAT VENTRICULAR MYOCYTES; SARCOPLASMIC-RETICULUM FUNCTION; DOCOSAHEXAENOIC ACID; EICOSAPENTAENOIC ACID; MYOCARDIAL-INFARCTION; FISH CONSUMPTION; LIPID-PEROXIDATION; MOLECULAR ACTIVITY;
D O I：
10.1007/s10974-016-9459-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Since 40 years, it is known that omega-3 poly-unsaturated fatty acids (omega 3 PUFAs) have cardioprotective effects. These include antiarrhythmic effects, improvements of autonomic function, endothelial function, platelet anti-aggregation and inflammatory properties, lowering blood pressure, plaque stabilization and reduced atherosclerosis. However, recently, conflicting results regarding the health benefits of omega 3 PUFAs from seafood or omega 3 PUFAs supplements have emerged. The aim of this review is to examine recent literature regarding health aspects of omega 3 PUFAs intake from fish or supplements, and to discuss different arguments/reasons supporting these conflicting findings.
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收藏
页码：25 / 30
页数：6
相关论文
共 74 条
  • [1] Differential sensitivities of the NCX1.1 and NCX1.3 isoforms of the Na+-Ca2+ exchanger to α-linolenic acid
    Ander, Bradley P.
    Hurtado, Cecilia
    Raposo, Carla S.
    Maddaford, Thane G.
    Deniset, Justin F.
    Hryshko, Larry V.
    Pierce, Grant N.
    Lukas, Anton
    [J]. CARDIOVASCULAR RESEARCH, 2007, 73 (02) : 395 - 403
  • [2] Omega-3s: Fishing for a Mechanism
    Anderson, Ethan J.
    Taylor, David A.
    [J]. SCIENTIST, 2012, 26 (11) : 36 - 41
  • [3] Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart
    Anderson, Ethan J.
    Katunga, Lalage A.
    Willis, Monte S.
    [J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2012, 39 (02): : 179 - 193
  • [4] Distribution, interconversion, and dose response of n-3 fatty acids in humans
    Arterburn, Linda M.
    Hall, Eileen Bailey
    Oken, Harry
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2006, 83 (06) : 1467S - 1476S
  • [5] DIETARY-INTAKE OF MARINE N-3 FATTY-ACIDS, FISH INTAKE, AND THE RISK OF CORONARY-DISEASE AMONG MEN
    ASCHERIO, A
    RIMM, EB
    STAMPFER, MJ
    GIOVANNUCCI, EL
    WILLETT, WC
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (15) : 977 - 982
  • [6] BANG HO, 1976, ACTA MED SCAND, V200, P69
  • [7] Dietary fish oil reduces the incidence of triggered arrhythmias in pig ventricular myocytes
    Berecki, Geza
    Den Ruijter, Hester M.
    Verkerk, Arie O.
    Schumacher, Cees A.
    Baartscheer, Antonius
    Bakker, Diane
    Boukens, Bastiaan J.
    van Ginneken, Antoni C. G.
    Fiolet, Jan W. T.
    Opthof, Tobias
    Coronel, Ruben
    [J]. HEART RHYTHM, 2007, 4 (11) : 1452 - 1460
  • [8] BILLMAN GE, 1991, J CARDIOVASC PHARM, V18, pS107
  • [9] The effects of omega-3 polyunsaturated fatty acids on cardiac rhythm: A critical reassessment
    Billman, George E.
    [J]. PHARMACOLOGY & THERAPEUTICS, 2013, 140 (01) : 53 - 80
  • [10] Omega-3 polyunsaturated fatty acids and cardiac rhythm: an introduction
    Billman, George E.
    [J]. FRONTIERS IN PHYSIOLOGY, 2012, 3
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