Controlled release hydrogen sulfide delivery system based on mesoporous silica nanoparticles protects graft endothelium from ischemia-reperfusion injury

被引：37
作者：
Wang, Wenshuo [1 ]
Sun, Xiaotian [1 ,2 ]
Zhang, Huili [3 ]
Yang, Cheng [1 ]
Liu, Ye [4 ,5 ]
Yang, Wuli [4 ,5 ]
Guo, Changfa [1 ]
Wang, Chunsheng [1 ]
机构：
[1] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiac Surg, 180 Fenglin Rd, Shanghai 200032, Peoples R China
[2] Fudan Univ, Huashan Hosp, Dept Cardiothorac Surg, Shanghai, Peoples R China
[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Cardiol, Shanghai 200030, Peoples R China
[4] Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai, Peoples R China
[5] Fudan Univ, Dept Macromol Sci, Shanghai, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2016年 / 11卷
关键词：
inflammatory response; rejection; cellular uptake; proliferation; cardiac allograft vasculopathy; CARDIAC ALLOGRAFT VASCULOPATHY; CELLS; TRANSPLANTATION; MECHANISMS; SURVIVAL; DISEASE; DONOR;
D O I：
10.2147/IJN.S104604
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Hydrogen sulfide (H2S) functions as a protective gas transmitter in various physiological and pathological processes, but the lack of ideal donors severely hampers the clinical application of H2S. This study aims to construct a controlled release H2S donor and evaluate its protective effect on graft endothelium. Mesoporous silica nanoparticles (MSNs) were synthesized using the sol-gel method and loaded with diallyl trisulfide (DATS), an H2S-releasing agent named DATS-MSN. In vitro experiments showed that DATS-MSN could alleviate endothelial cell inflammation and enhance endothelial cell proliferation and migration. In vivo experiments demonstrated that the apoptosis of graft endothelium was mitigated in the presence of DATS-MSN. Our results indicated that DATS-MSN, releasing H2S in a controlled release fashion, could serve as an ideal H2S donor.
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收藏
页码：3255 / 3263
页数：9
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