Evaluation of Mycobacterium bovis double knockout mce2-phoP as candidate vaccine against bovine tuberculosis

被引：17
|
作者：
Garcia, Elizabeth [1 ]
Bianco, Maria V. [1 ]
Jose Gravisaco, Maria [1 ]
Rocha, Rosana V. [1 ]
Blanco, Federico C. [1 ]
Bigi, Fabiana [1 ]
机构：
[1] CICVyA INTA, Inst Biotecnol, RA-1686 Hurlingham, Argentina
来源：
TUBERCULOSIS | 2015年 / 95卷 / 02期
关键词：
Vaccine; phoP; Bovine tuberculosis; Mycobacerium bovis; CHALLENGE; CATTLE; BCG;
D O I：
10.1016/j.tube.2015.01.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study, a Mycobacterium bovis knockout strain in phoP-phoR and mce2 operons was tested as an antituberculosis experimental vaccine in animal models. The double mutant strain was significantly more attenuated than the wild type strain in inmunocompetent and inmunodeficient mice. Vaccination with the double mutant protected mice against challenge with a virulent M. bovis strain. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：186 / 189
页数：4
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