Magnesium intoxication in women with preeclampsia with severe features treated with magnesium sulfate

被引：5

作者：

Akbar, Muhammad Ilham Aldika ^{[1
,2
,3
]}

Yoseph, Daniel ^{[2
]}

Aditiawarman ^{[1
,2
]}

Bachnas, Muhammad Adrianes ^{[4
]}

Dachlan, Erry Gumilar ^{[1
,2
,3
]}

Dekker, Gustaaf Albert ^{[1
,5
]}

Ernawati ^{[1
,2
,3
]}

机构：

[1] Univ Airlangga, Fac Med, Dept Obstet & Gynecol, Surabaya, Indonesia

[2] DR Soetomo Gen Acad Hosp, Dept Obstet & Gynecol, Surabaya, Indonesia

[3] Univ Airlangga Hosp, Dept Obstet & Gynecol, Surabaya, Indonesia

[4] Univ Sebelas Maret, Dept Obstet & Gynecol, Dr Moewardi Gen Hosp, Fac Med, Surakarta, Indonesia

[5] Univ Adelaide, Lyell McEwin Hosp, Dept Obstet & Gynecol, Adelaide, SA, Australia

来源：

HYPERTENSION IN PREGNANCY | 2020年 / 39卷 / 03期

关键词：

Magnesium intoxication; hypermagnesemia; magnesium sulfate; preeclampsia with severe features; HYPERTENSIVE DISORDERS; MAGPIE TRIAL; PREGNANCY; ECLAMPSIA; MANAGEMENT; PLACEBO;

D O I：

10.1080/10641955.2020.1754851

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To evaluate the maternal-neonatal outcome in magnesium (Mg)-intoxicated women with preeclampsia with severe features (PESF) treated with magnesium sulfate (MgSO4). Methods: A total of 19 Mg intoxicated PESF women (cases) were compared with 166 PESF women without signs of intoxication (controls). Results: Mg serum levels of cases was higher compared to control group (12.36 +/- 3.54 mg/dl versus 2.69 +/- 0.83 mg/dl). 3 women died and 3 had major maternal morbidity in cases group compared with zero in the control group (P = 0.009). Mg intoxication was also significantly associated with perinatal deaths and low Apgar scores at 1 and 5 minutes. Conclusion: Mg intoxication is associated with a increased risk of maternal and perinatal mortality and morbidity.

引用

页码：221 / 227

页数：7

共 26 条

[1]

[Anonymous], BMC PREGNANCY CHILDB

[2] A low dose ('Dhaka') magnesium sulphate regime for eclampsia - Clinical findings and serum magnesium levels [J].

Begum, R ;

Begum, A ;

Johanson, R ;

Ali, MN ;

Akhter, S .

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2001, 80 (11) :998-1002

[3]

Cunningham FG, 2015, CHESLEY'S HYPERTENSIVE DISORDERS IN PREGNANCY, 4TH EDITION, P25, DOI 10.1016/B978-0-12-407866-6.00002-X

[4] MATERNAL MORTALITY ASSOCIATED WITH HYPERTENSIVE DISORDERS OF PREGNANCY IN AFRICA, ASIA, LATIN-AMERICA AND THE CARIBBEAN [J].

DULEY, L .

BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1992, 99 (07) :547-553

[5] Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial [J].

Duley, L ;

Farrell, B ;

Spark, P ;

Roberts, B ;

Watkins, K ;

Bricker, L ;

Wang, L ;

Armstrong, N ;

Tivnin, M ;

Salih, N ;

Hurst, A ;

Smyth, R ;

Cooper, S ;

Wilson, A ;

Bowler, U ;

Notman, J .

LANCET, 2002, 359 (9321) :1877-1890

[6]

DULEY L, 2003, MAGNESIUM SULPHATE O

[7] The Magpie Trial:: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia.: Outcome for children at 18 months [J].

Duley, Lelia ;

Farrell, Barbara ;

Armstrong, Nina ;

Spark, Patsy ;

Roberts, Barbara ;

Smyth, Rebecca ;

Tivnan, Mary ;

Laws, Anna ;

Corfield, Noelene ;

Salter, Annette ;

Thorn, Lisa ;

Altman, Douglas ;

Yu, Ly-Mee ;

Abalos, Edgardo ;

Carroli, Berenise ;

Dellepiane, Lucrecia ;

Duarte, Marina ;

Fernandez, Hebe ;

Giordano, Daniel ;

Altman, Douglas ;

Armstrong, Nina ;

Clarke, Mike ;

Duley, Lelia ;

Farrell, Barbara ;

Gray, Alastair ;

Hey, Edmund ;

Neilson, James ;

Simon, Judit ;

Spark, Patsy ;

Smyth, Rebecca ;

Yu, Ly-Mee ;

Doyle, Lex ;

Hey, Edmund ;

Kelly, Tom ;

Squires, Jane ;

Altman, Douglas ;

Collins, Rory ;

Duley, Lelia ;

Farrell, Barbara ;

Karaoglou, Anna ;

Lilford, Richard ;

Moodley, Jack ;

Neilson, James ;

Robson, Stephen ;

Roberts, Ian ;

Rubin, Peter ;

Thornton, James ;

Twaddle, Sara ;

Villar, Jose ;

Walker, Isabel .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2007, 114 (03) :289-299

[8] Magnesium Sulphate for the Management of Preeclampsia and Eclampsia in Low and Middle Income Countries: A Systematic Review of Tested Dosing Regimens [J].

Gordon, Rebecca ;

Magee, Laura A. ;

Payne, Beth ;

Firoz, Tabassum ;

Sawchuck, Diane ;

Tu, Domena ;

Vidler, Marianne ;

de Silva, Dane ;

von Dadelszen, Peter .

JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA, 2014, 36 (02) :154-163

[9]

GRISSINGER M, 2009, PHARM THER, V34

[10] Magnesium in Prevention and Therapy [J].

Groeber, Uwe ;

Schmidt, Joachim ;

Kisters, Klaus .

NUTRIENTS, 2015, 7 (09) :8199-8226

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