Negative influence of programmed death-1-ligands on the survival of esophageal cancer patients treated with chemotherapy

被引:49
作者
Tanaka, Koji [1 ]
Miyata, Hiroshi [1 ]
Sugimura, Keijiro [1 ]
Kanemura, Takashi [1 ]
Hamada-Uematsu, Mika [2 ]
Mizote, Yu [2 ,3 ]
Yamasaki, Makoto [1 ]
Wada, Hisashi [1 ]
Nakajima, Kiyokazu [1 ]
Takiguchi, Shuji [1 ]
Mori, Masaki [1 ]
Doki, Yuichiro [1 ]
Tahara, Hideaki [2 ]
机构
[1] Osaka Univ, Dept Gastroenterol Surg, Grad Sch Med, Suita, Osaka, Japan
[2] Univ Tokyo, Dept Surg & Bioengn, Adv Clin Res Ctr, Inst Med Sci, Tokyo 1088639, Japan
[3] Sanofi KK, Tokyo, Japan
关键词
Chemotherapy; esophageal cancer; prognosis; programmed death-1-ligand; programmed death-2-ligand; SQUAMOUS-CELL CARCINOMA; PHASE-II; CISPLATIN; SAFETY; 5-FLUOROURACIL; EXPRESSION; ANTI-PD-1; ANTIBODY; DOCETAXEL; PROGNOSIS;
D O I
10.1111/cas.12938
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The programmed death-1/programmed death-1 ligands (PD-1/PD-L) pathway plays an important role in immunological tumor evasion. However, the clinical significance of the PD-L (L1 and L2) expression in esophageal cancer treated with chemotherapy has not been fully investigated. We examined the expression of PD-L of the primary tumors obtained from 180 esophageal cancer patients who underwent radical resection with or without neoadjuvant chemotherapy (NAC) using immunohistochemical staining. The relationship between the expression patterns and clinico-pathological characteristics was examined. In the present study, 53 patients (29.4%) and 88 patients (48.3%) were classified into positive for PD-L1 and PD-L2 expression, respectively. In all the patients examined, overall survival rates of the patients with tumors positive for PD-L1 or PD-L2 were significantly worse than those with tumors negative for PD-L1 or PD-L2 (P = 0.0010 and P = 0.0237, respectively). However, subgroup analysis showed that these tendencies are only found in the patients treated with NAC, and not in those without NAC. The patients with positive PD-L1 expression had a significantly higher rate of NAC history (P = 0.0139), but those with positive PD-L2 expression did not have a significantly high rate of NAC history (P = 0.6127). There is no significant relationship between PD-L1 expression and response to chemotherapy (P = 0.3118), but patients with positive PD-L2 expression had significantly inferior responses to chemotherapy (P = 0.0034). The PD-1/PD-L pathway might be an immunological mechanism associated with the long-term effectiveness of chemotherapy in esophageal cancer patients. Further investigation into the roles of PD-1 pathway in chemotherapy could lead to the development of better treatment options for this disease.
引用
收藏
页码:726 / 733
页数:8
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