A finite element model to predict the consequences of endolymphatic hydrops in the basilar membrane

被引:6
作者
Areias, Bruno [1 ]
Parente, Marco P. L. [1 ,2 ]
Gentil, Fernanda [3 ]
Caroca, Cristina [4 ,5 ]
Paco, Joao [4 ,5 ]
Natal Jorge, Renato M. [1 ,2 ]
机构
[1] Inst Sci & Innovat Mech & Ind Engn, INEGI, Porto, Portugal
[2] Univ Porto, FEUP, Fac Engn, Porto, Portugal
[3] Escola Super Saude Politecn Porto, Clin ORL Dr Eurico de Almeida, WIDEX, Porto, Portugal
[4] Univ Nova Lisboa, Nucleo Acad Clin Otorrinolaringol & Cirurgia Cerv, Lisbon, Portugal
[5] Univ Nova Lisboa, NOVA Med Sch, Comprehens Hlth Res Ctr, Lisbon, Portugal
关键词
basilar membrane; cochlea; endolymphatic hydrops; hearing; Meniere's disease; MENIERES-DISEASE; SOUND-TRANSMISSION; PATHOPHYSIOLOGY; PREVALENCE; DIAGNOSIS; PERILYMPH; STIFFNESS; HEARING;
D O I
10.1002/cnm.3541
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Meniere's disease is an inner ear disorder, associated with episodes of vertigo, fluctuant hearing loss, tinnitus, and aural fullness. Meniere's disease is associated with endolymphatic hydrops. Clinical evidences show that this disease is often incapacitating, negatively affecting the patients' everyday life. The pathogenesis of Meniere's disease is still not fully understood and remains unclear. Previous numerical studies available in the literature related with endolymphatic hydrops, are very scarce. The present work applies the finite element method to investigate the consequences of endolymphatic hydrops in the normal hearing, associated with the Meniere's disease. The obtained results for the steady state dynamics analysis are in accordance with clinical evidences. The results show that the basilar membrane is not affected in the same intensity along its length and that the lower frequencies are more affected by the endolymphatic hydrops. From a clinical point of view, this work shows the relationship between the increasing of the endolymphatic pressure and the development of hearing loss.
引用
收藏
页数:13
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