Physalis angulata concentrated ethanolic extract suppresses nociception and inflammation by modulating cytokines and prostanoids pathways

被引：9

作者：

do Espirito Santo, Renan Fernandes ^{[1
,2
]}

Lima, Milena da Silva ^{[1
]}

Lima Juiz, Paulo Jose ^{[3
]}

Franca Opretzka, Luiza Carolina ^{[1
]}

Nogueira, Renata Campos ^{[2
]}

Ribeiro, Ivone Maria ^{[4
]}

Barbosa Tomassini, Therezinha Coelho ^{[4
]}

Pereira Soares, Milena Botelho ^{[2
]}

Villarreal, Cristiane Flora ^{[1
,2
]}

机构：

[1] Univ Fed Bahia, Fac Farm, Salvador, BA, Brazil

[2] Fiocruz MS, Inst Goncalo Moniz, Salvador, BA, Brazil

[3] Univ Fed Reconcavo Bahia, Ctr Ciencia & Tecnol Energia & Sustentabilidade, Feira De Santana, BA, Brazil

[4] Fiocruz MS, Farmanguinhos, Rio De Janeiro, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 22期

关键词：

Anti-inflammatory; antinociception; immunomodulation; physalins; herbal drug extracts; CEEPA; concentrated ethanolic extract from Physalis angulata; L;

D O I：

10.1080/14786419.2019.1705812

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Physalins are seco-steroids with a variety of pharmacological activities already described. In this study the pharmacological properties of a standardized concentrated ethanolic extract from Physalis angulata (CEEPA), rich in physalins B, D, F and G, were studied in models of pain and inflammation in mice. Inflammatory mediators were measured by radioimmunoassay and Real-Time PCR in mice paws after the CFA stimuli. Systemic administration of CEEPA produced antinociceptive effect on the writhing test and formalin test. In the writhing test, physalins B, D, F and G showed that the antinociceptive effect of CEEPA is more potent than that of these purified compounds. In addition, CEEPA reduced the levels of TNF-alpha, IL-1 beta, COX-2 and iNOS mRNA in the CFA-induced paw inflammation. Likewise, CEEPA decreased the TNF-alpha, IL-1 beta and PGE(2) paw levels. In conclusion, CEEPA induces antinociceptive and anti-inflammatory effects, with improved pharmacological potency relative to pure physalins, associated to modulation of cytokine and cyclooxygenase pathways.

引用

页码：4675 / 4679

页数：5

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