Long intergenic non-protein coding RNA 460: Review of its role in carcinogenesis

被引：6
作者：
Ghafouri-Fard, Soudeh [1 ]
Khoshbakht, Tayyebeh [2 ]
Taheri, Mohammad [3 ]
Hajiesmaeili, Mohammadreza [4 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Mens Hlth & Reprod Hlth Res Ctr, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Skull Base Res Ctr, Tehran, Iran
[4] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Crit Care Qual Improvement Res Ctr, Tehran, Iran
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2021年 / 225卷
关键词：
Long intergenic  non-protein coding  RNA; 460; Long  non-coding  Cancer; SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; NONCODING RNA; CANCER PROGRESSION; DOWN-REGULATION; LUNG-CANCER; LINC00460; PROLIFERATION; INVASION; HEAD;
D O I：
10.1016/j.prp.2021.153556
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Long intergenic non-coding RNAs (lincRNAs) establish a group of long non-coding RNAs (lncRNAs) that have no overlap with protein-coding genes. These transcripts have been found to affect chromatin configurations, arrange high-order nuclear structures, function as scaffolds for proteins and RNAs and serve as molecular decoys. LINC00460 is a member of this group of lincRNAs that participate in the pathoetiology of cancers. This lincRNA has been found to serve as a sponge for a number of tumor suppressor miRNAs, including miR-539, miR-1224-5p, miR-612, miR-342-3p, miR-485-5p and miR-149-5p, and increase expression of oncogenic targets of these miRNAs. Moreover, through targeting miRNAs that regulate sensitivity to chemotherapeutic agents, it can affect response of cancer cells to these agents. In the current manuscript, we tended to describe the role of LINC00460 in this process through summarizing the results of in vitro, in vivo and human studies.
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页数：10
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