GRAY MATTER ALTERATIONS IN PAROSMIA

被引：38

作者：

Bitter, T. ^{[1
]}

Siegert, F. ^{[1
]}

Gudziol, H. ^{[1
]}

Burmeister, H. P. ^{[2
]}

Mentzel, H. -J. ^{[2
]}

Hummel, T. ^{[3
]}

Gaser, C. ^{[4
]}

Guntinas-Lichius, O. ^{[1
]}

机构：

[1] Univ Jena, Dept Otorhinolaryngol, Jena, Germany

[2] Univ Jena, Inst Diagnost & Intervent Radiol, Jena, Germany

[3] Univ Dresden, Sch Med, Dept Otorhinolaryngol, Smell & Taste Clin, Dresden, Germany

[4] Univ Jena, Dept Psychiat, Jena, Germany

来源：

NEUROSCIENCE | 2011年 / 177卷

关键词：

human; olfaction; parosmia; volumetry; magnetic resonance imaging; insula; OLFACTORY-BULB VOLUME; ODOR-DISCRIMINATION; PERCEPTION; PREVALENCE; INSULA; SMELL;

D O I：

10.1016/j.neuroscience.2011.01.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parosmia is a common olfactory disorder. In this condition, odors are perceived in a different quality than usual. This distorted olfactory percept is typically reported to be unpleasant. Little is known about the pathophysiology of this phenomenon. Previous studies demonstrated smaller volumes of the olfactory bulbs in patients with parosmia compared to subjects without parosmia. In order to investigate structural brain alterations in areas beyond the olfactory bulb, in the current study voxel-based morphometry was applied. A group of 22 parosmic patients was compared with control subjects matched for age- and sex, who exhibited a similar performance in olfactory tests. Performing a whole brain analysis, we found profound gray matter volume loss in the left anterior insula in parosmic patients. In an additional volume of interest analysis including primary and secondary olfactory areas, we also found volume loss in the right anterior insula, the anterior cingulate cortex, the hippocampus bilaterally, and the left medial orbitofrontal cortex. Many of these areas are critically involved in olfactory quality discrimination and odor memory. The present results indicate that reduced gray matter volume in brain regions supporting odor discrimination and memory is related to disturbed olfactory sensation in parosmia. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：177 / 182

页数：6

共 34 条

[1]

Abolmaali N, 2008, NEUROIMAG CLIN N AM, V18, P233, DOI 10.1016/j.nic.2007.10.002

[2] Unified segmentation [J].