Gut microbiota is critical for the induction of chemotherapy-induced pain

被引：229

作者：

Shen, Shiqian ^{[1
]}

Lim, Grewo ^{[1
]}

You, Zerong ^{[1
]}

Ding, Weihua ^{[2
]}

Huang, Peigen ^{[3
,4
]}

Ran, Chongzhao ^{[5
]}

Doheny, Jason ^{[1
]}

Caravan, Peter ^{[5
]}

Tate, Samuel ^{[1
]}

Hu, Kun ^{[1
]}

Kim, Hyangin ^{[1
]}

McCabe, Michael ^{[1
]}

Huang, Bo ^{[6
]}

Xie, Zhongcong ^{[7
]}

Kwon, Douglas ^{[4
,8
,9
]}

Chen, Lucy ^{[1
]}

Mao, Jianren ^{[1
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, MGH Ctr Translat Pain Res, Boston, MA 02115 USA

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Anesthesia & Pain Med, Hangzhou, Zhejiang, Peoples R China

[3] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA

[4] Harvard Med Sch, Boston, MA USA

[5] Harvard Med Sch, Massachusetts Gen Hosp, MGH HST Athinoula A Martinos Ctr Biomed Imaging, Boston, MA USA

[6] Chinese Acad Med Sci, Basic Sci Inst, Beijing, Peoples R China

[7] Harvard Med Sch, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Geriatr Anesthesia Res Unit, Boston, MA USA

[8] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA

[9] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

来源：

NATURE NEUROSCIENCE | 2017年 / 20卷 / 09期

关键词：

PERIPHERAL MONONEUROPATHY; PACLITAXEL; CONTRIBUTES; HYPERALGESIA; RESPONSES; THERAPY; RATS;

D O I：

10.1038/nn.4606

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechanical hyperalgesia was reduced in germ-free mice and in mice pretreated with antibiotics. Restoring the microbiota of germ-free mice abrogated this protection. These effects appear to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages.

引用

页码：1213 / +

页数：6

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