The chemistry and biology of antimitotic chalcones and related enone systems

被引：86

作者：

Lawrence, NJ ^{[1
]}

McGown, AT

机构：

[1] Univ S Florida, H Lee Moffitt Canc Ctr & Res Inst, Drug Discovery Program, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA

[2] Univ Salford, Dept Chem, Ctr Mol Drug Design, Manchester M5 5WT, Lancs, England

来源：

CURRENT PHARMACEUTICAL DESIGN | 2005年 / 11卷 / 13期

关键词：

D O I：

10.2174/1381612053764733

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The development of combretastatin as an antimitotic agent has led to an enormous effort to design other tubulin-targeting agents. The intriguing discovery that combretastatin A-4 phosphate causes selective damage to tumor vasculature has stimulated even more activity in this field. This attention to tubulin binding agents and their antivasculature activity is highly likely to lead to significant clinical advances for the treatment of cancer. This review focuses on the development of ketones as tubulin-binding agents such as chalcones and related enones as Surrogates of combretastatin and colchicine.

引用

页码：1679 / 1693

页数：15

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