AQUEOUS HUMOR AND PLASMA LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND INTERLEUKIN-8 IN PATIENTS WITH CENTRAL SEROUS CHORIORETINOPATHY

Purpose: The purpose of this study was to determine aqueous vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) levels in patients with central serous chorioretinopathy (CSC) before a single intravitreal bevacizumab injection. Methods: Twelve eyes with symptomatic CSC were included. Samples from patients with cataracts served as controls. The levels of VEGF and IL-8 concentrations were measured in aqueous humor and plasma by multiplex bead assays. Results: All patients with CSC showed an improvement in visual acuity and resolved neurosensory detachment after intravitreal bevacizumab injection. The aqueous humor levels of VEGF and IL-8 were not significantly increased in patients with CSC compared with the healthy control group (18.2 +/- 24.8 vs. 35.3 +/- 28.5 pg/mL, P > 0.05; 2.3 +/- 0.4 vs. 2.8 +/- 0.3 pg/mL, P. 0.05, respectively). The plasma levels of VEGF and IL-8 in patients with CSC were not different from those in the healthy control group. Conclusion: Vascular endothelial growth factor and IL-8 were not increased in the aqueous humor and plasma of patients with CSC. The effect of intravitreal bevacizumab injection as a treatment for CSC must be fully understood, and the true effect of anti-VEGF treatment in patients with CSC remains to be elucidated. RETINA 30: 1465-1471, 2010