Risk Factors Associated With Outpatient Parenteral Antibiotic Therapy Program Failure Among Intravenous Drug Users

被引：46

作者：

Buehrle, Deanna J. ^{[1
]}

Shields, Ryan K. ^{[1
]}

Shah, Neel ^{[1
]}

Shoff, Christopher ^{[1
]}

Sheridan, Kathleen ^{[1
]}

机构：

[1] Univ Pittsburgh, Pittsburgh, PA 15260 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2017年 / 4卷 / 03期

关键词：

OPAT; IVDU; IVDA; outpatient antibiotics; ADVERSE EVENTS; HOSPITALIZATIONS; OPAT;

D O I：

10.1093/ofid/ofx102

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sixty-one percent of intravenous drug users (IVDUs) who received outpatient parenteral antibiotic therapy (OPAT) failed treatment. Hospital readmission and adverse drug reactions occurred in 25%. By multivariate analysis, time since last IVDU was associated with failure (P=.04). Intravenous drug users requiring OPAT are at high risk for failure; additional studies are needed to explore alternatives.

引用

收藏

页码：1 / 4

页数：4

相关论文

共 15 条

[1]

[Anonymous], 2015, HHS PUBL

[2] Clinical efficacy and cost-effectiveness of outpatient parenteral antibiotic therapy (OPAT): a UK perspective [J].

Chapman, Ann L. N. ;

Dixon, Simon ;

Andrews, Dawn ;

Lillie, Patrick J. ;

Bazaz, Rohit ;

Patchett, Julie D. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2009, 64 (06) :1316-1324

[3] Nationwide increase in hospitalizations for heroin-related soft tissue infections: Associations with structural market conditions [J].

Ciccarone, Daniel ;

Unick, George Jay ;

Cohen, Jenny K. ;

Mars, Sarah G. ;

Rosenblum, Daniel .

DRUG AND ALCOHOL DEPENDENCE, 2016, 163 :126-133

[4] Adverse drug reactions: definitions, diagnosis, and management [J].

Edwards, IR ;

Aronson, JK .

LANCET, 2000, 356 (9237) :1255-1259

[5] Oral antibiotic therapy in infective endocarditis [J].

Fuller, RE ;

Hayward, SL .

ANNALS OF PHARMACOTHERAPY, 1996, 30 (06) :676-678

[6] Safe and successful treatment of intravenous drug users with a peripherally inserted central catheter in an outpatient parenteral antibiotic treatment service [J].

Ho, Jennifer ;

Archuleta, Sophia ;

Sulaiman, Zuraidah ;

Fisher, Dale .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2010, 65 (12) :2641-2644

[7]

Lai A, 2013, AM J MANAG CARE, V19

[8] Hospitalizations Related To Opioid Abuse/Dependence And Associated Serious Infections Increased Sharply, 2002-12 [J].

Ronan, Matthew V. ;

Herzig, Shoshana J. .

HEALTH AFFAIRS, 2016, 35 (05) :832-837

[9] Outcomes and Pharmacoeconomic Analysis of a Home Intravenous Antibiotic Infusion Program in Veterans [J].

Ruh, Christine A. ;

Parameswaran, Ganapathi I. ;

Wojciechowski, Amy L. ;

Mergenhagen, Kari A. .

CLINICAL THERAPEUTICS, 2015, 37 (11) :2527-2535

[10] Factors associated with outcome and duration of therapy in outpatient parenteral antibiotic therapy (OPAT) patients with skin and soft-tissue infections [J].

Seaton, R. A. ;

Sharp, E. ;

Bezlyak, V. ;

Weir, C. J. .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2011, 38 (03) :243-248