Deep brain stimulation in clinical trials and animal models of depression

被引：58
作者：
Hamani, Clement [1 ,2 ]
Nobrega, Jose N. [1 ]
机构：
[1] Ctr Addict & Mental Hlth, Neuroimaging Res Sect, Toronto, ON M5T 1R8, Canada
[2] Toronto Western Hosp, Div Neurosurg, Toronto, ON M5T 2S8, Canada
来源：
EUROPEAN JOURNAL OF NEUROSCIENCE | 2010年 / 32卷 / 07期
关键词：
animal models; deep brain stimulation; depression; psychiatry; MEDIAL PREFRONTAL CORTEX; PRELIMBIC-INFRALIMBIC CORTICES; ADVANCED PARKINSON-DISEASE; FORCED SWIMMING TEST; ELECTRICAL-STIMULATION; MAJOR DEPRESSION; WORKING-MEMORY; EFFERENT PROJECTIONS; RESPONSE SELECTION; ANTERIOR CINGULATE;
D O I：
10.1111/j.1460-9568.2010.07414.x
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Deep brain stimulation (DBS) is currently being investigated as a therapy for the treatment of depression. Despite promising results of recent clinical trials, neural and chemical mechanisms responsible for the effects of stimulation are still unclear. In this article, we review clinical and laboratory findings on DBS for depression. Particular emphasis will be given to aspects involved in the translation of data from animal models to humans and in our findings on the potential substrates involved in the antidepressant effects of DBS in rats.
引用
收藏
页码：1109 / 1117
页数：9
相关论文
共 102 条
[71]  
Paxinos G, 1998, RAT BRAIN IN STEREOTAXIC COORDINATES, FOURTH ED., pix
[72]   BEHAVIORAL DESPAIR IN RATS - NEW MODEL SENSITIVE TO ANTIDEPRESSANT TREATMENTS [J].
PORSOLT, RD ;
ANTON, G ;
BLAVET, N ;
JALFRE, M .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 47 (04) :379-391
[73]   DEPRESSION - NEW ANIMAL-MODEL SENSITIVE TO ANTIDEPRESSANT TREATMENTS [J].
PORSOLT, RD ;
LEPICHON, M ;
JALFRE, M .
NATURE, 1977, 266 (5604) :730-732
[74]   Neurocircuitry of Mood Disorders [J].
Price, Joseph L. ;
Drevets, Wayne C. .
NEUROPSYCHOPHARMACOLOGY, 2010, 35 (01) :192-216
[75]   The role of ventromedial prefrontal cortex in the recovery of extinguished fear [J].
Quirk, GJ ;
Russo, GK ;
Barron, JL ;
Lebron, K .
JOURNAL OF NEUROSCIENCE, 2000, 20 (16) :6225-6231
[76]   The effects of prelimbic and infralimbic lesions on working memory for visual objects in rats [J].
Ragozzino, ME ;
Detrick, S ;
Kesner, RP .
NEUROBIOLOGY OF LEARNING AND MEMORY, 2002, 77 (01) :29-43
[77]   Differential involvement of the dorsal anterior cingulate and prelimbic-infralimbic areas of the rodent prefrontal cortex in spatial working memory [J].
Ragozzino, ME ;
Adams, S ;
Kesner, RP .
BEHAVIORAL NEUROSCIENCE, 1998, 112 (02) :293-303
[78]   WHICH ELEMENTS ARE EXCITED IN ELECTRICAL-STIMULATION OF MAMMALIAN CENTRAL NERVOUS-SYSTEM - REVIEW [J].
RANCK, JB .
BRAIN RESEARCH, 1975, 98 (03) :417-440
[79]   Pressor and tachycardic responses evoked by microinjections of L-glutamate into the medial prefrontal cortex of unanaesthetized rats [J].
Resstel, LBM ;
Corrêa, FMA .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 21 (09) :2513-2520
[80]   Capsulotomy for obsessive-compulsive disorder -: Long-term follow-up of 25 patients [J].
Ruck, Christian ;
Karlsson, Andreas ;
Steele, J. Douglas ;
Edman, Gunnar ;
Meyerson, Bjoern A. ;
Ericson, Kaj ;
Nyman, Hakan ;
Asberg, Marie ;
Svanborg, Paer .
ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (08) :914-922
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