Deep brain stimulation in clinical trials and animal models of depression

被引：58

作者：

Hamani, Clement ^{[1
,2
]}

Nobrega, Jose N. ^{[1
]}

机构：

[1] Ctr Addict & Mental Hlth, Neuroimaging Res Sect, Toronto, ON M5T 1R8, Canada

[2] Toronto Western Hosp, Div Neurosurg, Toronto, ON M5T 2S8, Canada

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2010年 / 32卷 / 07期

关键词：

animal models; deep brain stimulation; depression; psychiatry; MEDIAL PREFRONTAL CORTEX; PRELIMBIC-INFRALIMBIC CORTICES; ADVANCED PARKINSON-DISEASE; FORCED SWIMMING TEST; ELECTRICAL-STIMULATION; MAJOR DEPRESSION; WORKING-MEMORY; EFFERENT PROJECTIONS; RESPONSE SELECTION; ANTERIOR CINGULATE;

D O I：

10.1111/j.1460-9568.2010.07414.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Deep brain stimulation (DBS) is currently being investigated as a therapy for the treatment of depression. Despite promising results of recent clinical trials, neural and chemical mechanisms responsible for the effects of stimulation are still unclear. In this article, we review clinical and laboratory findings on DBS for depression. Particular emphasis will be given to aspects involved in the translation of data from animal models to humans and in our findings on the potential substrates involved in the antidepressant effects of DBS in rats.

引用

页码：1109 / 1117

页数：9

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