Impact on growth, oxidative stress, and apoptosis-related gene transcription of zebrafish after exposure to low concentration of arsenite

被引：36

作者：

Dong, Wen-Qi ^{[1
]}

Sun, Hong-Jie ^{[1
]}

Zhang, Yu ^{[1
]}

Lin, Hong-Jun ^{[1
]}

Chen, Jian-Rong ^{[1
]}

Hong, Hua-Chang ^{[1
]}

机构：

[1] Zhejiang Normal Univ, Coll Geog & Environm Sci, Jinhua 321004, Zhejiang, Peoples R China

来源：

CHEMOSPHERE | 2018年 / 211卷

关键词：

Arsenite; Zebrafish; Oxidative stress; Oxidative damage; Apoptosis; CARP HYPOPHTHALMICHTHYS-NOBILIS; LIPID-PEROXIDATION; TOXICITY; WATER; EXPRESSION; RESPONSES; REMOVAL; LIVER; ARSENIC(III); ADSORBENT;

D O I：

10.1016/j.chemosphere.2018.08.010

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Low concentrations of arsenic (As) contamination in aquatic environment is a worldwide issue, which is of great concern. To evaluate the impact of low concentrations of As on zebrafish, we measured the growth, antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT), oxidative damage (malondialdehyde, MDA) and apoptosis-related genes (nrf2, p53 and c-jun) of adult zebrafish after exposing to different AsIII concentrations (0, 10, 50, 100 or 150 mu g L-1) for 28 d. Results indicated that exposure to low AsIII concentrations decreased the zebrafish weight by 14%, increased the activities of SOD and CAT by 23-41% and 31-59%, decreased the contents of MDA by 29-54%, and modulated transcription of apoptosis related genes. Our study showed that chronic exposure to AsIII concentrations <150 mu g L-1 generated oxidative stress and damage on zebrafish, and altered apoptosis-related genes in zebrafish. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：648 / 652

页数：5

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