Organocatalytic asymmetric multi-component [C+NC+CC] synthesis of highly functionalized pyrrolidine derivatives

被引：108

作者：

Ibrahem, Ismail ^{[1
]}

Rios, Ramon ^{[1
]}

Vesely, Jan ^{[1
]}

Cordova, Armando ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 36期

关键词：

ENANTIOSELECTIVE 1,3-DIPOLAR CYCLOADDITION; AZOMETHINE YLIDES; CONJUGATE ADDITION; ONE-POT; ORGANIC CATALYSIS; ALPHA; BETA-UNSATURATED ALDEHYDES; STEREOSELECTIVE-SYNTHESIS; MICHAEL REACTION; 3-COMPONENT; STRATEGIES;

D O I：

10.1016/j.tetlet.2007.07.031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly cherno- and enantioselective organocatalytic [C+NC+CC] coupling process between aldehydes, dialkyl 2aminornalonates and a,p-unsaturated aldehydes is presented. The reaction gives access to highly functionalized pyrrolidine derivatives in good yields with > 10:1 dr and 90-98% ee. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6252 / 6257

页数：6

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