Laboratory testing for antiphospholipid syndrome

被引：19

作者：

Pengo, V. ^{[1
,2
]}

Banzato, A. ^{[1
,2
]}

Bison, E. ^{[1
,2
]}

Denas, G. ^{[1
,2
]}

Zoppellaro, G. ^{[1
,2
]}

Bracco, A. ^{[1
,2
]}

Jose, S. Padayattil ^{[1
,2
]}

Hoxha, A. ^{[3
]}

Ruffatti, A. ^{[3
]}

机构：

[1] Univ Padua, Clin Cardiol, Dept Cardiac Thorac & Vasc Sci, Padua, Italy

[2] Univ Padua, Div Rheumatol, Padua, Italy

[3] Univ Padua, Dept Med, Padua, Italy

来源：

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY | 2016年 / 38卷

关键词：

Phospholipid; syndrome; testing; laboratory; 1ST THROMBOEMBOLIC EVENT; LUPUS ANTICOAGULANT; ANTIBODY PROFILE; CLINICAL-COURSE; ANTICARDIOLIPIN; PERFORMANCE; POSITIVITY; DIAGNOSIS; CARRIERS; UPDATE;

D O I：

10.1111/ijlh.12507

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This is a practical report on laboratory tests for the diagnosis of antiphospholipid syndrome (APS). After a general definition of APS, this study deals with appropriateness and timing in requesting the determination of antiphospholipid (aPL) antibodies. Lupus anticoagulant (LAC), anticardiolipin (aCL), and anti 2-glycoprotein I (aGPI) are the mandatory tests to be performed, while other tests are not yet validated for clinical use. Interpretation of results is an important discussed issue that implies a close liaison between clinical pathologists and clinicians. Finally, a personal definition of APS according to aPL antibody profile closes the manuscript.

引用

页码：27 / 31

页数：5

共 26 条

[11] Value of Isolated IgA Anti-β2-Glycoprotein I Positivity in the Diagnosis of the Antiphospholipid Syndrome [J].

Murthy, Vijaya ;

Willis, Rohan ;

Romay-Penabad, Zurina ;

Ruiz-Limon, Patricia ;

Martinez-Martinez, Laura A. ;

Jatwani, Shraddha ;

Jajoria, Praveen ;

Seif, Alan ;

Alarcon, Graciela S. ;

Papalardo, Elizabeth ;

Liu, Jigna ;

Vila, Luis M. ;

McGwin, Gerald, Jr. ;

McNearney, Terry A. ;

Maganti, Rashmi ;

Sunkureddi, Prashanth ;

Parekh, Trisha ;

Tarantino, Michael ;

Akhter, Ehtisham ;

Fang, Hong ;

Gonzalez, Emilio B. ;

Binder, Walter R. ;

Norman, Gary L. ;

Shums, Zakera ;

Teodorescu, Marius ;

Reveille, John D. ;

Petri, Michelle ;

Pierangeli, Silvia S. .

ARTHRITIS AND RHEUMATISM, 2013, 65 (12) :3186-3193

[12]

OOSTING JD, 1992, THROMB HAEMOSTASIS, V67, P499

[13] Antibody profiles for the diagnosis of anti phospholipid syndrome [J].

Pengo, V ;

Biasiolo, A ;

Pegoraro, C ;

Cucchini, U ;

Noventa, F ;

Iliceto, S .

THROMBOSIS AND HAEMOSTASIS, 2005, 93 (06) :1147-1152

[14] Antibodies to Domain 4/5 (Dm4/5) of β2-Glycoprotein 1 (β2GP1) in different antiphospholipid (aPL) antibody profiles [J].

Pengo, V. ;

Ruffatti, A. ;

Tonelloa, M. ;

Hoxha, A. ;

Bison, E. ;

Denas, G. ;

Jose, S. Padayattil ;

Zoppellaro, G. ;

Bracco, A. ;

Banzato, A. .

THROMBOSIS RESEARCH, 2015, 136 (01) :161-163

[15] Antiphospholipid syndrome: antibodies to Domain 1 of β2-glycoprotein 1 correctly classify patients at risk [J].

Pengo, V. ;

Ruffatti, A. ;

Tonello, M. ;

Cuffaro, S. ;

Banzato, A. ;

Bison, E. ;

Denas, G. ;

Jose, S. Padayattil .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2015, 13 (05) :782-787

[16] Clinical course of high-risk patients diagnosed with antiphospholipid syndrome [J].

Pengo, V. ;

Ruffatti, A. ;

Legnani, C. ;

Gresele, P. ;

Barcellona, D. ;

Erba, N. ;

Testa, S. ;

Marongiu, F. ;

Bison, E. ;

Denas, G. ;

Banzato, A. ;

Jose, S. Padayattil ;

Iliceto, S. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2010, 8 (02) :237-242

[17] Update of the guidelines for lupus anticoagulant detection [J].

Pengo, V. ;

Tripodi, A. ;

Reber, G. ;

Rand, J. H. ;

Ortel, T. L. ;

Galli, M. ;

de Groot, P. G. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 (10) :1737-1740

[18] Anti phospholipid antibody ELISAs:: Survey on the performance of clinical laboratories assessed by using lyophilized affinity-purifled IgG with anticardiolipin and anti-β2-glycoprotein I activity [J].

Pengo, Vittorio ;

Biasiolo, Alessandra ;

Bison, Elisa ;

Chantarangkul, Veena ;

Tripodi, Armando .

THROMBOSIS RESEARCH, 2007, 120 (01) :127-133

[19] Incidence of a first thromboembolic event in carriers of isolated lupus anticoagulant [J].

Pengo, Vittorio ;

Testa, Sophie ;

Martinelli, Ida ;

Ghirarduzzi, Angelo ;

Legnani, Cristina ;

Gresele, Paolo ;

Passamonti, Serena M. ;

Bison, Elisa ;

Denas, Gentian ;

Jose, Seena Padayattil ;

Banzato, Alessandra ;

Ruffatti, Amelia .

THROMBOSIS RESEARCH, 2015, 135 (01) :46-49

[20] Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study [J].

Pengo, Vittorio ;

Ruffatti, Amelia ;

Legnani, Cristina ;

Testa, Sophie ;

Fierro, Tiziana ;

Marongiu, Francesco ;

De Micheli, Valeria ;

Gresele, Paolo ;

Tonello, Marta ;

Ghirarduzzi, Angelo ;

Bison, Elisa ;

Denas, Gentian ;

Banzato, Alessandra ;

Jose, Seena Padayattil ;

Iliceto, Sabino .

BLOOD, 2011, 118 (17) :4714-4718

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