Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology

被引：142
作者：
Desrochers, Laura M. [1 ]
Antonyak, Marc A. [1 ]
Cerione, Richard A. [1 ]
机构：
[1] Cornell Univ, Dept Mol Med, Ithaca, NY 14853 USA
来源：
DEVELOPMENTAL CELL | 2016年 / 37卷 / 04期
关键词：
TUMOR-DERIVED MICROVESICLES; MESSENGER-RNAS; INTERCELLULAR COMMUNICATION; INTRACELLULAR TRAFFICKING; MULTIVESICULAR BODY; ACTIVATED PLATELETS; MEMBRANE-VESICLES; IN-VIVO; EXOSOMES; ANGIOGENESIS;
D O I：
10.1016/j.devcel.2016.04.019
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The generation and shedding of extracellular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of intercellular communication with important roles in several physiological processes and diseases such as cancer. These membrane-enclosed packets can transfer specific proteins, RNA transcripts, microRNAs, and even DNA to target cells, thereby altering their function. Despite the exponential growth of the EV field, a great deal remains unclear about the mechanisms that regulate exosome and MV biogenesis, as well as about how to isolate different classes of EVs and how to best take advantage of them for clinical applications.
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收藏
页码：301 / 309
页数：9
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