Direct release of nitriles from solid phase

被引：8

作者：

Hone, ND

Payne, LJ

Tice, CM

机构：

[1] Merrifield Ctr, Cambridge Discovery Chem, Cambridge CB1 3LQ, England

[2] Rohm & Haas Co, Spring House, PA 19477 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 06期

关键词：

solid phase synthesis; combinatorial chemistry; libraries; nitriles; biphenyls;

D O I：

10.1016/S0040-4039(00)01988-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cleavage conditions are described which allow resin bound secondary amides to be liberated from Sieber or Rink resin as nitriles. The method has been applied to the synthesis of a series of cyanobiaryls. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：1115 / 1118

页数：4

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