Recent advances in the total synthesis of monoterpenoid indole alkaloids enabled by asymmetric catalysis

被引：31

作者：

Liu, Xiao-Yu

Qin, Yong ^{[1
]}

机构：

[1] Sichuan Univ, Sichuan Engn Lab Plant Sourced Drug, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst,Educ M, Chengdu 610041, Peoples R China

来源：

GREEN SYNTHESIS AND CATALYSIS | 2022年 / 3卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Asymmetric catalysis; Total synthesis; Indole alkaloid; Natural product; Enantioselectivity; PICTET-SPENGLER REACTIONS; ENANTIOSELECTIVE TOTAL-SYNTHESIS; ASPIDOSPERMA ALKALOIDS; EFFICIENT SYNTHESIS; MICHAEL ADDITION; ALKYLATION; STRATEGY; ACIDS; CONSTRUCTION; ALDEHYDES;

D O I：

10.1016/j.gresc.2021.10.009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric catalysis has continued to enable the preparation of optically active natural products over the past decade. This minireview summarizes progress in the catalytic enantioselective total synthesis of complex mon-oterpenoid indole alkaloids covering the reports from 2019 to June 2021. In particular, the generation of the key chiral stereogenic centers with metal catalysts and organocatalysts has been highlighted, showcasing the power of asymmetric catalysis protocols in accessing complex molecular architectures.

引用

页码：25 / 39

页数：15

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