Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives

被引：147

作者：

Mashino, T

Shimotohno, K

Ikegami, N

Nishikawa, D

Okuda, K

Takahashi, K

Nakamura, S

Mochizuki, M

机构：

[1] Kyoritsu Univ Pharm, Minato Ku, Tokyo, Japan

[2] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 04期

关键词：

fullerene; anti-HIV; anti-HCV; reverse transcriptase; RNA-dependent RNA polymerase;

D O I：

10.1016/j.bmcl.2004.12.030

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We examined the human immunodeficiency virus-reverse transcriptase and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of cationic, anionic, and amino acid-type fullerene derivatives. Among the fullerene derivatives, the amino acid-type fullerene derivative was the most efficient in human immunodeficiency virus-reverse transcriptase inhibition. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1107 / 1109

页数：3

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