Cationic Pd(II) complexes acting as topoisomerase II inhibitors: Synthesis, characterization, DNA interaction and cytotoxicity

被引：23

作者：

Rocha, Fillipe V. ^{[1
,2
]}

Barra, Carolina V. ^{[1
]}

Garrido, Saulo S. ^{[3
]}

Manente, Francine A. ^{[4
]}

Carlos, Iracilda Z. ^{[4
]}

Ellena, Javier ^{[5
]}

Fuentes, Andrea S. C. ^{[6
]}

Gautier, Arnaud ^{[7
]}

Morel, Laurent ^{[8
]}

Mauro, Antonio E. ^{[1
]}

Netto, Adelino V. G. ^{[1
]}

机构：

[1] UNESP, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, Brazil

[2] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP, Brazil

[3] UNESP, Inst Quim, Dept Bioquim & Tecnol Quim, BR-14801970 Araraquara, SP, Brazil

[4] UNESP Univ Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Dept Anal Clin, POB 502, BR-14801902 Araraquara, SP, Brazil

[5] Univ Sao Paulo, Inst Fis, BR-13560970 Sao Carlos, SP, Brazil

[6] Univ Fed Sao Carlos, Dept Genet & Evolut, Mol Biol Lab, Rodovia Washington Luis Km 235, BR-13565905 Sao Carlos, SP, Brazil

[7] Univ Blaise Pascal, Clermont Univ, CNRS, ICCF,UMR 6296, F-63177 Aubiere, France

[8] Univ Blaise Pascal, Clermont Univ, INSERM, GreD UMR CNRS 6247,U931, 24 Ave Landais, F-63177 Aubiere, France

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2016年 / 159卷

基金：

巴西圣保罗研究基金会;

关键词：

CATHEPSIN-B; MECHANISMS; AGENTS; ALPHA; SERIES; DAMAGE; DRUGS;

D O I：

10.1016/j.jinorgbio.2016.02.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：165 / 168

页数：4

共 32 条

[11]

Hande K.R., UPDATE CANC THERAPEU, P13

[12] Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II [J].

Hasinoff, BB ;

Wu, X ;

Begleiter, A ;

Guziec, LJ ;

Guziec, F Jr ;

Giorgianni, A ;

Yang, SH ;

Jiang, Y ;

Yalowich, JC .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2006, 57 (02) :221-233

[13] Biochemical and proteomics approaches to characterize topoisomerase IIα cysteines and DNA as targets responsible for cisplatin-induced inhibition of topoisomerase IIα [J].

Hasinoff, BB ;

Wu, X ;

Krokhin, OV ;

Ens, W ;

Standing, KG ;

Nitiss, JL ;

Sivaram, T ;

Giorgianni, A ;

Yang, SH ;

Jiang, Y ;

Yalowich, JC .

MOLECULAR PHARMACOLOGY, 2005, 67 (03) :937-947

[14] CHEMICAL AND BIOLOGICAL PROPERTIES OF A NEW SERIES OF CIS-DIAMMINEPLATINUM(II) ANTITUMOR AGENTS CONTAINING 3 NITROGEN DONORS - CIS-[PT(NH3)2(N-DONOR)CL]+ [J].

HOLLIS, LS ;

AMUNDSEN, AR ;

STERN, EW .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (01) :128-136

[15] A Series of α-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase IIα Catalytic Activity [J].

Huang, He ;

Chen, Qin ;

Ku, Xin ;

Meng, Linghua ;

Lin, Liping ;

Wang, Xiang ;

Zhu, Caihua ;

Wang, Yi ;

Chen, Zhi ;

Li, Ming ;

Jiang, Hualiang ;

Chen, Kaixian ;

Ding, Jian ;

Liu, Hong .

JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (08) :3048-3064

[16] Influence of terminal substitution on structural, DNA, Protein binding, anticancer and antibacterial activities of palladium(II) complexes containing 3-methoxy salicylaldehyde-4(N) substituted thiosemicarbazones [J].

Kalaivani, P. ;

Prabhakaran, R. ;

Ramachandran, E. ;

Dallemer, F. ;

Paramaguru, G. ;

Renganathan, R. ;

Poornima, P. ;

Padma, V. Vijaya ;

Natarajan, K. .

DALTON TRANSACTIONS, 2012, 41 (08) :2486-2499

[17]

KAWANISHI S, 1972, CHEM PHARM BULL, V20, P262

[18] Catalytic topoisomerase II inhibitors in cancer therapy [J].

Larsen, AK ;

Eseargueil, AE ;

Skladanowski, A .

PHARMACOLOGY & THERAPEUTICS, 2003, 99 (02) :167-181

[19] Tumor cell death induced by topoisomerase-targeting drugs [J].

Li, TK ;

Liu, LF .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2001, 41 :53-77

[20] DNA topoisomerase II, genotoxicity, and cancer [J].

McClendon, A. Kathleen ;

Osheroff, Neil .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2007, 623 (1-2) :83-97

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