Cationic Pd(II) complexes acting as topoisomerase II inhibitors: Synthesis, characterization, DNA interaction and cytotoxicity

被引:23
作者
Rocha, Fillipe V. [1 ,2 ]
Barra, Carolina V. [1 ]
Garrido, Saulo S. [3 ]
Manente, Francine A. [4 ]
Carlos, Iracilda Z. [4 ]
Ellena, Javier [5 ]
Fuentes, Andrea S. C. [6 ]
Gautier, Arnaud [7 ]
Morel, Laurent [8 ]
Mauro, Antonio E. [1 ]
Netto, Adelino V. G. [1 ]
机构
[1] UNESP, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, Brazil
[2] Univ Fed Sao Carlos, Dept Chem, BR-13565905 Sao Carlos, SP, Brazil
[3] UNESP, Inst Quim, Dept Bioquim & Tecnol Quim, BR-14801970 Araraquara, SP, Brazil
[4] UNESP Univ Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Dept Anal Clin, POB 502, BR-14801902 Araraquara, SP, Brazil
[5] Univ Sao Paulo, Inst Fis, BR-13560970 Sao Carlos, SP, Brazil
[6] Univ Fed Sao Carlos, Dept Genet & Evolut, Mol Biol Lab, Rodovia Washington Luis Km 235, BR-13565905 Sao Carlos, SP, Brazil
[7] Univ Blaise Pascal, Clermont Univ, CNRS, ICCF,UMR 6296, F-63177 Aubiere, France
[8] Univ Blaise Pascal, Clermont Univ, INSERM, GreD UMR CNRS 6247,U931, 24 Ave Landais, F-63177 Aubiere, France
基金
巴西圣保罗研究基金会;
关键词
CATHEPSIN-B; MECHANISMS; AGENTS; ALPHA; SERIES; DAMAGE; DRUGS;
D O I
10.1016/j.jinorgbio.2016.02.039
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:165 / 168
页数:4
相关论文
共 32 条
[1]   Synthesis, cytotoxic activity and DNA interaction of Pd(II) complexes bearing N′-methyl-3,5-dimethyl-1-thiocarbamoylpyrazole [J].
Barra, Carolina V. ;
Rocha, Fillipe V. ;
Gautier, Arnaud ;
Morel, Laurent ;
Quilles, Marcela B. ;
Carlos, Iracilda Z. ;
Treu-Filho, Oswaldo ;
Frem, Regina C. G. ;
Mauro, Antonio E. ;
Netto, Adelino V. G. .
POLYHEDRON, 2013, 65 :214-220
[2]   Chiral cyclopalladated complexes derived from N,N-dimethyl-1-phenethylamine with bridging bis(diphenylphosphine)ferrocene ligand as inhibitors of the cathepsin B activity and as antitumoral agents [J].
Bincoletto, C ;
Tersariol, ILS ;
Oliveira, CR ;
Dreher, S ;
Fausto, DM ;
Soufen, MA ;
Nascimento, FD ;
Caires, ACF .
BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (08) :3047-3055
[3]   Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme [J].
Burden, DA ;
Osheroff, N .
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1998, 1400 (1-3) :139-154
[4]   Ras stimulates DNA topoisomerase IIα through MEK:: A link between oncogenic signaling and a therapeutic target [J].
Chen, G ;
Templeton, D ;
Suttle, DP ;
Stacey, DW .
ONCOGENE, 1999, 18 (50) :7149-7160
[5]   The cytotoxicity and mechanisms of 1,2-naphtoquinone thiosemicarbazone and its metal derivatives against MCF-7 human breast cancer cells [J].
Chen, JN ;
Huang, YW ;
Liu, GS ;
Afrasiabi, Z ;
Sinn, E ;
Padhye, S ;
Ma, Y .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2004, 197 (01) :40-48
[6]   Click Chelators - The Behavior of Platinum and Palladium Complexes in the Presence of Guanosine and DNA [J].
Chevry, Aurelien ;
Teyssot, Marie-Laure ;
Maisonial, Aurelie ;
Lemoine, Pascale ;
Viossat, Bernard ;
Traikia, Mounir ;
Aitken, David J. ;
Alves, Georges ;
Morel, Laurent ;
Nauton, Lionel ;
Gautier, Arnaud .
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2010, (22) :3513-3519
[7]   Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases [J].
Corbett, KD ;
Berger, JM .
ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2004, 33 :95-118
[8]   Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice [J].
Fortune, JM ;
Osheroff, N .
PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 64, 2000, 64 :221-253
[9]   DNA Binding, Photocleavage, and Topoisomerase Inhibition of Functionalized Ruthenium(II)-Polypyridine Complexes [J].
Gao, Feng ;
Chao, Hui ;
Ji, Liang-Nian .
CHEMISTRY & BIODIVERSITY, 2008, 5 (10) :1962-1979
[10]   Inhibitory effect of the sugarcane cystatin CaneCPI-4 on cathepsins B and L and human breast cancer cell invasion [J].
Gianotti, Andreia ;
Sommer, Csar A. ;
Carmona, Adriana K. ;
Henrique-Silva, Flavio .
BIOLOGICAL CHEMISTRY, 2008, 389 (04) :447-453