Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells

被引：52

作者：

Quang, DN

Hashimoto, T

Arakawa, Y

Kohchi, C

Nishizawa, T

Soma, GI

Asakawa, Y

机构：

[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Tokushima 7708514, Japan

[2] Tokushima Bunri Univ, Inst Hlth & Sci, Tokushima 7708514, Japan

[3] Tokyo Univ Sci, Inst Drug Delivery Syst, Noda, Chiba 2788510, Japan

[4] Hanoi Univ Educ, Fac Chem, Hanoi, Vietnam

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 01期

基金：

日本学术振兴会;

关键词：

fungi; Albatrellus caeruleoporus; grifolinone; grifolin; nitric oxide;

D O I：

10.1016/j.bmc.2005.08.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new farnesyl phenols named grifolinones A and B, together with known grifolin and neogrifolin, were isolated from methanolic extract of the inedible mushroom Albatrellus caeruleoporus. Their structures were characterized by a combination of 2D NMR, MS, IR, and UV spectra. Grifolinone B was composed of two grifolin Molecules, which were connected by a C-C bond. Grifolinones A and B, grifolin, and neogrifolin exhibited inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with IC50 values of 23.4, 22.9, 29.0, and 23.3 mu M, respectively. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：164 / 168

页数：5

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