Open Targets Platform: new developments and updates two years on

被引：311

作者：

Carvalho-Silva, Denise ^{[1
,2
]}

Pierleoni, Andrea ^{[1
,2
]}

Pignatelli, Miguel ^{[1
,2
]}

Ong, ChuangKee ^{[1
,2
]}

Fumis, Luca ^{[1
,2
]}

Karamanis, Nikiforos ^{[1
,2
]}

Carmona, Miguel ^{[1
,2
]}

Faulconbridge, Adam ^{[1
,2
]}

Hercules, Andrew ^{[1
,2
]}

McAuley, Elaine ^{[1
,2
]}

Miranda, Alfredo ^{[1
,2
]}

Peat, Gareth ^{[1
,2
]}

Spitzer, Michaela ^{[1
,2
]}

Barrett, Jeffrey ^{[2
,3
]}

Hulcoop, David G. ^{[2
,4
]}

Papa, Eliseo ^{[2
,5
]}

Koscielny, Gautier ^{[2
,4
]}

Dunham, Ian ^{[1
,2
]}

机构：

[1] EBI, EMBL, Wellcome Genome Campus, Hinxton CB10 1SD, Cambs, England

[2] Open Targets, Wellcome Genome Campus, Hinxton CB10 1SD, Cambs, England

[3] Wellcome Sanger Inst, Wellcome Genome Campus, Cambridge CB10 1SA, England

[4] Med Res Ctr, GSK, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England

[5] Biogen, Cambridge, MA 02142 USA

来源：

NUCLEIC ACIDS RESEARCH | 2019年 / 47卷 / D1期

关键词：

GENOME-WIDE ASSOCIATION; CANCER; INFORMATION; HALLMARKS; DATABASE; ATLAS;

D O I：

10.1093/nar/gky1133

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Open Targets Platform integrates evidence from genetics, genomics, transcriptomics, drugs, animal models and scientific literature to score and rank target-disease associations for drug target identification. The associations are displayed in an intuitive user interface (https://www.targetvalidation.org), and are available through a REST-API (https://api.opentargets.io/v3/platform/docs/swagger-ui) and a bulk download (https://www.targetvalidation.org/downloads/data). In addition to target-disease associations, we also aggregate and display data at the target and disease levels to aid target prioritisation. Since our first publication two years ago, we have made eight releases, added new data sources for target-disease associations, started including causal genetic variants from non genome-wide targeted arrays, added new target and disease annotations, launched new visualisations and improved existing ones and released a new web tool for batch search of up to 200 targets. We have a new URL for the Open Targets Platform REST-API, new REST endpoints and also removed the need for authorisation for API fair use. Here, we present the latest developments of the Open Targets Platform, expanding the evidence and target-disease associations with new and improved data sources, refining data quality, enhancing website usability, and increasing our user base with our training workshops, user support, social media and bioinformatics forum engagement.

引用

页码：D1056 / D1065

页数：10

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