Mechanisms of kinetochore-microtubule attachment errors in mammalian oocytes

被引：30

作者：

Kitajima, Tomoya S. ^{[1
]}

机构：

[1] RIKEN, Lab Chromosome Segregat, Ctr Dev Biol, Kobe, Hyogo 6500047, Japan

来源：

DEVELOPMENT GROWTH & DIFFERENTIATION | 2018年 / 60卷 / 01期

关键词：

aneuploidy; chromosome segregation; kinetochore; microtubule; oocyte; CHROMOSOME BI-ORIENTATION; MOUSE OOCYTES; MEIOSIS-I; B56-PP2A PHOSPHATASE; MEIOTIC SPINDLE; KINASE-ACTIVITY; CROSS-LINKS; M-PHASE; ANEUPLOIDY; PROTEIN;

D O I：

10.1111/dgd.12410

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proper kinetochore-microtubule attachment is essential for correct chromosome segregation. Therefore, cells normally possess multiple mechanisms for the prevention of errors in kinetochore-microtubule attachments and for selective stabilization of correct attachments. However, the oocyte, a cell that produces an egg through meiosis, exhibits a high frequency of errors in kinetochore-microtubule attachments. These attachment errors predispose oocytes to chromosome segregation errors, resulting in aneuploidy in eggs. This review aims to provide possible explanations for the error-prone nature of oocytes by examining key differences among other cell types in the mechanisms for the establishment of kinetochore-microtubule attachments.

引用

页码：33 / 43

页数：11

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