Current Management of Gestational Trophoblastic Neoplasia

被引：118
作者：
Goldstein, Donald Peter [1 ]
Berkowitz, Ross S. [2 ,3 ]
机构：
[1] Harvard Univ, Sch Med, Dana Farber Brigham & Womens Canc Ctr, Div Gynecol Oncol,New England Trophoblast Dis Ctr, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Boston, MA 02115 USA
[3] Dana Farber Canc Inst, Boston, MA 02115 USA
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2012年 / 26卷 / 01期
关键词：
Gestational trophoblastic neoplasia; Invasive mole; Choriocarcinoma; Human chorionic gonadotropin; WEEKLY INTRAMUSCULAR METHOTREXATE; HUMAN CHORIONIC-GONADOTROPIN; GYNECOLOGIC-ONCOLOGY-GROUP; RETROSPECTIVE COHORT SURVEY; COMPLETE MOLAR PREGNANCY; CENTRAL-NERVOUS-SYSTEM; EMA-CO CHEMOTHERAPY; DOSE ACTINOMYCIN-D; OF-THE-LITERATURE; HYDATIDIFORM MOLE;
D O I：
10.1016/j.hoc.2011.10.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gestational trophoblastic neoplasms are malignant lesions that arise from placental villous and extravillous trophoblast. Four clinicopathologic conditions make up this entity: invasive mole (IM), choriocarcinoma (CCA), placental-site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (El I). IM and CCA, which make up the majority of these tumors, are highly responsive to chemotherapy with an overall cure rate exceeding 90%, making it usually possible to achieve cure while preserving reproductive function. PSTT and ETT, which rarely occur, are relatively resistant to chemotherapy, making surgery the primary treatment modality, chemotherapy being used only when the disease has metastasized.
引用
收藏
页码：111 / +
页数：23
相关论文
共 134 条
[1]  
Alazzam M, 2009, COCHRANE DB SYST REV, V1
[2]  
Allison KH, 2006, ARCH PATHOL LAB MED, V130, P1875
[3]   EPIDEMIOLOGY OF HYDATIDIFORM MOLE DURING EARLY GESTATION [J].
ATRASH, HK ;
HOGUE, CJR ;
GRIMES, DA .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1986, 154 (04) :906-909
[4]  
AYHAN A, 1990, J REPROD MED, V35, P522
[5]  
AZAB M, 1989, CANCER-AM CANCER SOC, V64, P1829, DOI 10.1002/1097-0142(19891101)64:9<1829::AID-CNCR2820640912>3.0.CO
[6]  
2-G
[7]   Placental site trophoblastic tumor: A study of 55 cases and review of the literature emphasizing factors of prognostic significance [J].
Baergen, RN ;
Rutgers, JL ;
Young, RH ;
Osann, K ;
Scully, RE .
GYNECOLOGIC ONCOLOGY, 2006, 100 (03) :511-520
[8]  
BAGSHAWE KD, 1986, LANCET, V2, P673
[9]  
BAGSHAWE KD, 1976, CANCER-AM CANCER SOC, V38, P112, DOI 10.1002/1097-0142(197607)38:1<112::AID-CNCR2820380120>3.0.CO
[10]  
2-P
12345678910