Euglycemic Diabetic Ketoacidosis in a Pregnant Woman With Severe COVID-19: A Case Report

被引:9
作者
Harman, Megan L. [1 ]
Cuellar, Emery M. [1 ]
Denora, Allyson R. Burkhart [2 ]
Pokhriyal, Megha [1 ]
Mussarat, Saad [1 ]
机构
[1] Eastern Virginia Med Sch, Internal Med, Norfolk, VA 23501 USA
[2] Naval Med Ctr Portsmouth, Internal Med, Portsmouth, Hants, England
关键词
hypoxemic respiratory failure; euglycemic; diabetic ketoacidosis; pregnancy; covid-19;
D O I
10.7759/cureus.21649
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Euglycemic diabetic ketoacidosis (DKA) of pregnancy is an uncommon but serious condition that poses a substantial risk to the fetus. The physiological state of pregnancy itself predisposes women to ketosis and ketoacidosis, which can be further exacerbated by acute stressors such as infection. In this article, we describe a case of a pregnant woman with gestational diabetes and coronavirus disease 2019 (COVID-19) requiring mechanical ventilation who developed euglycemic DKA during her hospital course. Despite treating the patient with standard DKA protocol, fetal heart monitoring was non-reassuring and, hence, a cesarean section was performed. Postoperatively, her DKA resolved; however, she was maintained on supportive ventilation for continued management of her severe COVID-19 infection. In light of the ongoing pandemic, it is essential that healthcare teams closely monitor pregnant women presenting with COVID-19 infection for early signs of euglycemic DKA so that treatment may be initiated early and feto-maternal complications are avoided.
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页数:5
相关论文
共 20 条
[1]  
ACOG, 2021, COVID19 VACC CONS OB
[2]   β-Cell adaptation in pregnancy [J].
Baeyens, L. ;
Hindi, S. ;
Sorenson, R. L. ;
German, M. S. .
DIABETES OBESITY & METABOLISM, 2016, 18 :63-70
[3]   Metabolic Syndrome and COVID 19: Endocrine-Immune-Vascular Interactions Shapes Clinical Course [J].
Bansal, Rashika ;
Gubbi, Sriram ;
Muniyappa, Ranganath .
ENDOCRINOLOGY, 2020, 161 (10)
[4]   Awareness of euglycaemic diabetic ketoacidosis during pregnancy prevents recurrence of devastating outcomes: a case report of two pregnancies in one patient [J].
Dargel, Susanne ;
Schleussner, Ekkehard ;
Kloos, Christof ;
Groten, Tanja ;
Weschenfelder, Friederike .
BMC PREGNANCY AND CHILDBIRTH, 2021, 21 (01)
[5]  
Edwards M, 2021, StatPearls
[6]   Starvation ketoacidosis in pregnancy [J].
Frise, Charlotte J. ;
Mackillop, Lucy ;
Joash, Karen ;
Williamson, Catherine .
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2013, 167 (01) :1-7
[7]  
Gandhi M, 1995, Int. J. Diab. Dev. Ctries, V15, P132
[8]   An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible Mechanisms [J].
Hayden, Melvin R. .
CELLS, 2020, 9 (11)
[9]  
Jaber Johnny F, 2019, Case Rep Crit Care, V2019, P8769714, DOI 10.1155/2019/8769714
[10]   COVID-19 infection may cause ketosis and ketoacidosis [J].
Li, Juyi ;
Wang, Xiufang ;
Chen, Jian ;
Zuo, Xiuran ;
Zhang, Hongmei ;
Deng, Aiping .
DIABETES OBESITY & METABOLISM, 2020, 22 (10) :1935-1941