Multivariate analysis of the pathologic features of esophageal squamous cell cancer: Tumor budding is a significant independent prognostic factor

被引：95

作者：

Koike, Masahiko ^{[1
]}

Kodera, Yasuhiro ^{[1
]}

Itoh, Yuichi ^{[1
]}

Nakayama, Goro ^{[1
]}

Fujiwara, Michitaka ^{[1
]}

Hamajima, Nobuyuki ^{[2
]}

Nakao, Akimasa ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Surg 2, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Prevent Med Biostat & Med Decis Making, Showa Ku, Nagoya, Aichi 4668550, Japan

来源：

ANNALS OF SURGICAL ONCOLOGY | 2008年 / 15卷 / 07期

关键词：

tumor budding; prognosis; esophageal cancer; squamous cell cancer; esophagectomy;

D O I：

10.1245/s10434-008-9901-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Tumor budding has been suggested to be a prognostic factor in various cancers but has never been studied in esophageal cancer. Methods: In this study, the microscopic finding of tumor budding in esophageal squamous cell carcinoma was correlated with outcome after esophagectomy. One hundred and thirty-six patients undergoing a curative esophagectomy were assigned to either a frequent (n = 82) or rare (n = 54) group according to the microscopically observed frequency of tumor budding in the tumor. Results: The 5-year survival rates after esophagectomy were 35.4% for the frequent group and 81.3% for the rare group. Multivariate analysis using the Cox proportional hazards model by a stepwise method identified this morphological variable as a significant independent prognostic factor. Conclusions: Tumor budding in esophageal squamous cell carcinoma reflects the biological activity of the tumor and may be a useful prognostic indicator.

引用

页码：1977 / 1982

页数：6

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