Arginine supplementation reduces colonic injury, inflammation and oxidative stress of DSS-induced colitis in mice

被引：19

作者：

Rabelo Andrade, Maria Emilia ^{[1
]}

Vieira de Barros, Patricia Aparecida ^{[2
]}

dos Reis Menta, Penelope Lacrisio ^{[2
]}

Ferreira Costa, Grazielle Mara ^{[3
]}

Mendes Miranda, Sued Eustaquio ^{[4
]}

Lacerda Leocadio, Paola Caroline ^{[2
]}

de Almeida-Leite, Camila Megale ^{[3
]}

Generoso, Simone de Vasconcelos ^{[5
]}

Alvarez Leite, Jacqueline Isaura ^{[2
]}

Cardoso, Valbert Nascimento ^{[4
]}

机构：

[1] Univ Fed Minas Gerais, Fac Farm, Dept Alimentos, Av Presidente Antonio Carlos 667, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Av Presidente Antonio Carlos 667, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Morfol, Av Presidente Antonio Carlos 667, BR-31270901 Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Fac Farm, Dept Anal Clin & Toxicol, Av Presidente Antonio Carlos 667, BR-31270901 Belo Horizonte, MG, Brazil

[5] Univ Fed Minas Gerais, Escola Enfermagem, Dept Nutr, Av Prof Alfredo Balena 190, BR-30130100 Belo Horizonte, MG, Brazil

来源：

JOURNAL OF FUNCTIONAL FOODS | 2019年 / 52卷

关键词：

Arginine; DSS-induced colitis; Intestinal mucosa; Collagen; Nitric oxide; BOWEL-DISEASE; INTESTINAL PERMEABILITY; AMINO-ACIDS; MODELS; PRETREATMENT; INCREASES; NUTRITION; FIBROSIS; RATS;

D O I：

10.1016/j.jff.2018.11.019

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study evaluated the mechanisms action of arginine in experimental model of ulcerative colitis. C57BL/6 mice were randomized into 4 groups: Control group (C): standard diet; Colitis group (Col): standard diet and DSS solution; Pretreated group (PT): diet supplementation with arginine before and during colitis induction; Treated group (T): diet supplementation with arginine during colitis induction. Colitis was induced by administration of 1.5% DSS for 5 days. Parameters such as intestinal permeability (IP), bacterial translocation (BT), histological and morphometric analysis, cytokines, immunoglobulin A, inflammatory infiltrate, oxidative stress, tight junction, iNOS(1) were performed. The Col group showed increased IP, BT, oxidative stress and inflammatory infiltrate in the colon. Arginine decreased IP, BT, oxidative stress and inflammatory infiltrate in the colon. Only, the group T reduced iNOS, cytokine IL-17,(2) and increased collagen area and cytokine TGF-beta.(3) These results suggest that arginine can constitute in potential therapy for colitis.

引用

页码：360 / 369

页数：10

共 49 条

[1] cis-Urocanic Acid Attenuates Acute Dextran Sodium Sulphate-Induced Intestinal Inflammation [J].