Synthesis of 3-(aminomethylene)-2-oxoindolines by palladium-catalyzed annulation of 3-chloro-2-iodo-N-arylacrylamides with amides or amines

被引：8
作者：
Deng, Guo-Bo [2 ]
Wang, Zhi-Qiang [2 ]
Song, Ren-Jie [2 ]
Zhou, Ming-Bo [2 ]
Wei, Wen-Ting [2 ]
Xie, Peng [2 ]
Li, Jin-Heng [1 ]
机构：
[1] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
[2] Hunan Normal Univ, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ, Changsha 410081, Hunan, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 28期
关键词：
C-H FUNCTIONALIZATION; STEREOSELECTIVE-SYNTHESIS; CYCLIZATION REACTION; OXINDOLE SYNTHESIS; 2-(ALKYNYL)ARYL ISOCYANATES; 2-ALKYNYLARYL ISOCYANATES; BOND FUNCTIONALIZATION; SELECTIVE SYNTHESIS; KINASE INHIBITORS; DIRECT ARYLATION;
D O I：
10.1039/c1cc11602a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new palladium-catalyzed C-H bond activation-annulation-amination tandem method was presented for selectively synthesizing 3-(aminomethylene)-2-oxoindolines. In the presence of Pd(dba)(2), xantphos (L8), AgOAc and Na2CO3, a variety of 3-chloro-2-iodo-N-arylacrylamides underwent the reaction with amides or amines to afford the corresponding 3-(aminomethylene)2-oxoindolines in moderate to good yields.
引用
收藏
页码：8151 / 8153
页数：3
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