Synthesis of 3-(aminomethylene)-2-oxoindolines by palladium-catalyzed annulation of 3-chloro-2-iodo-N-arylacrylamides with amides or amines

被引：8

作者：

Deng, Guo-Bo ^{[2
]}

Wang, Zhi-Qiang ^{[2
]}

Song, Ren-Jie ^{[2
]}

Zhou, Ming-Bo ^{[2
]}

Wei, Wen-Ting ^{[2
]}

Xie, Peng ^{[2
]}

Li, Jin-Heng ^{[1
]}

机构：

[1] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China

[2] Hunan Normal Univ, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ, Changsha 410081, Hunan, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 28期

关键词：

C-H FUNCTIONALIZATION; STEREOSELECTIVE-SYNTHESIS; CYCLIZATION REACTION; OXINDOLE SYNTHESIS; 2-(ALKYNYL)ARYL ISOCYANATES; 2-ALKYNYLARYL ISOCYANATES; BOND FUNCTIONALIZATION; SELECTIVE SYNTHESIS; KINASE INHIBITORS; DIRECT ARYLATION;

D O I：

10.1039/c1cc11602a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new palladium-catalyzed C-H bond activation-annulation-amination tandem method was presented for selectively synthesizing 3-(aminomethylene)-2-oxoindolines. In the presence of Pd(dba)(2), xantphos (L8), AgOAc and Na2CO3, a variety of 3-chloro-2-iodo-N-arylacrylamides underwent the reaction with amides or amines to afford the corresponding 3-(aminomethylene)2-oxoindolines in moderate to good yields.

引用

页码：8151 / 8153

页数：3

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