Multimodal probe for optical coherence tomography epidetection and micron-scale indentation

被引:4
作者
Bartolini, L. [1 ]
Feroldi, F.
Weda, J. J. A.
Slaman, M.
de Boer, J. F.
Iannuzzi, D.
机构
[1] Vrije Univ Amsterdam, Dept Phys & Astron, Boelelaan 1081, NL-1081 HV Amsterdam, Netherlands
基金
欧洲研究理事会;
关键词
Optomechanical; microindentation; optical coherence tomography; indentation; multimodal sensor; epidetection; ELASTOGRAPHY; TISSUE; MECHANICS; HYDROGELS; CARTILAGE; STRAIN; SKIN; OCT;
D O I
10.1142/S179354581742007X
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We present a multimodal ferrule-top sensor designed to perform the integrated epidetection of Optical Coherence Tomography (OCT) depth-proflles and micron-scale indentation by all-optical detection. By scanning a sample under the probe, we can obtain structural cross-section images and identify a region-of-interest in a nonhomogeneous sample. Then, with the same probe and setup, we can immediately target that area with a series of spherical-indentation measurements, in which the applied load is known with a mu N precision, the indentation depth with sub-mu m precision and a maximum contact radius of 100 mu m. Thanks to the visualization of the internal structure of the sample, we can gain a better insight into the observed mechanical behavior. The ability to impart a small, confined load, and perform OCT A-scans at the same time, could lead to an alternative, high transverse resolution, Optical Coherence Elastography (OCE) sensor.
引用
收藏
页数:9
相关论文
共 44 条
[1]   Characterizing tissue stiffness at the tip of a rigid needle using an opto-mechanical force sensor [J].
Beekmans, S. V. ;
Iannuzzi, D. .
BIOMEDICAL MICRODEVICES, 2016, 18 (01) :1-8
[2]   A metrological approach for the calibration of force transducers with interferometric readout [J].
Beekmans, S. V. ;
Iannuzzi, D. .
SURFACE TOPOGRAPHY-METROLOGY AND PROPERTIES, 2015, 3 (02)
[3]   ATOMIC FORCE MICROSCOPE [J].
BINNIG, G ;
QUATE, CF ;
GERBER, C .
PHYSICAL REVIEW LETTERS, 1986, 56 (09) :930-933
[4]  
BOS EJ, 2017, PLAST REC SUR GLOB, V5
[5]   Ferrule-top nanoindenter: An optomechanical fiber sensor for nanoindentation [J].
Chavan, D. ;
van de Watering, T. C. ;
Gruca, G. ;
Rector, J. H. ;
Heeck, K. ;
Slaman, M. ;
Iannuzzi, D. .
REVIEW OF SCIENTIFIC INSTRUMENTS, 2012, 83 (11)
[6]   Collecting optical coherence elastography depth profiles with a micromachined cantilever probe [J].
Chavan, Dhwajal ;
Mo, Jianhua ;
de Groot, Mattijs ;
Meijering, Anna ;
de Boer, Johannes F. ;
Iannuzzi, Davide .
OPTICS LETTERS, 2013, 38 (09) :1476-1478
[7]   Three-dimensional optical coherence micro-elastography of skeletal muscle tissue [J].
Chin, Lixin ;
Kennedy, Brendan F. ;
Kennedy, Kelsey M. ;
Wijesinghe, Philip ;
Pinniger, Gavin J. ;
Terrill, Jessica R. ;
McLaughlin, Robert A. ;
Sampson, David D. .
BIOMEDICAL OPTICS EXPRESS, 2014, 5 (09) :3090-3102
[8]  
Cowin S., 2007, TISSUE MECH
[9]   Elastic modulus and viscoelastic properties of full thickness skin characterised at micro scales [J].
Crichton, Michael L. ;
Chen, Xianfeng ;
Huang, Han ;
Kendall, Mark A. F. .
BIOMATERIALS, 2013, 34 (08) :2087-2097
[10]   The role of mechanics in biological and bio-inspired systems [J].
Egan, Paul ;
Sinko, Robert ;
LeDuc, Philip R. ;
Keten, Sinan .
NATURE COMMUNICATIONS, 2015, 6