Neuropilin-1 (NRP-1), a Novel Molecular Target of Glioma

被引：4

作者：

Chen, Lukui ^{[1
]}

Shi, Yan ^{[3
]}

Qiu, Rong ^{[2
]}

机构：

[1] Southeast Univ, Sch Med, Zhongda Hosp, Nanjing 210009, Peoples R China

[2] Southeast Univ, Zhongda Hosp, Dept Neurosurg, Nanjing 210009, Peoples R China

[3] Nanjing Med Univ, Affiliated Nanjing Hosp, Dept Neurosurg, Nanjing 210009, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2016年 / 16卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Neuropilin-1; Glioma; ENDOTHELIAL-GROWTH-FACTOR; MESENCHYMAL STEM-CELLS; SINGLE-BASE EXTENSION; SMOOTH-MUSCLE-CELLS; GASTRIC-CANCER RISK; MAGNETIC NANOPARTICLES; DNA HYBRIDIZATION; NORTHERN JIANGSU; DETECTION SYSTEM; GOLD NANORODS;

D O I：

10.1166/jnn.2016.11376

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper reviews the recent studies of Neuropilin-1 (NRP-1) as a novel molecular target of glioma. In this review, we introduce briefly the properties of the NRP-1. And then we focused on the role of NRP-1 in gliomas, including relationships of NRP-1 expression and glioma prognosis, NRP-1 signaling and p130Cas tyrosine phosphorylation in gliomas, NRP-1 and LD22-4, Sema3A-NRP-1 signaling in gliomas, NRP-1 in the HGF/SF autocrine pathway, NRP-1 and glioma stem-like cells. Finally, it is concluded that NRP-1 could potentially act as a novel therapeutical target of glioma.

引用

页码：6657 / 6666

页数：10

共 202 条

[1] Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis [J].

Abounader, R ;

Laterra, J .

NEURO-ONCOLOGY, 2005, 7 (04) :436-451

[2] In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis [J].

Abounader, R ;

Lal, B ;

Luddy, C ;

Koe, G ;

Davidson, B ;

Rosen, EM ;

Laterra, J .

FASEB JOURNAL, 2001, 15 (13) :108-+

[3] RGS proteins have a signalling complex: Interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins [J].

Abramow-Newerly, M ;

Roy, AA ;

Nunn, C ;

Chidiac, P .

CELLULAR SIGNALLING, 2006, 18 (05) :579-591

[4]

Afra D, 2002, LANCET, V359, P1011

[5]

Ahmadi M., 2013, J BIONANOSCI, V7, P503

[6] Epigenetic Deregulations in Gastric Cancer [J].

Ali, Zeeshan ;

Deng, Yan ;

Tang, Yongjun ;

Zheng, Shuang ;

Ma, Ningning ;

He, Nongyue .

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2013, 13 (01) :40-51

[7]

[Anonymous], ADV SCI ENG MED

[8]

[Anonymous], 2013, J GREEN SCI TECHNOL

[9] Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding [J].

Appleton, Brent A. ;

Wu, Ping ;

Maloney, Janice ;

Yin, Jian Ping ;

Liang, Wei-Ching ;

Stawicki, Scott ;

Mortara, Kyle ;

Bowman, Krista K. ;

Elliott, J. Michael ;

Desmarais, William ;

Bazan, J. Fernando ;

Bagri, Anil ;

Tessier-Lavigne, Marc ;

Koch, Alexander W. ;

Wu, Yan ;

Watts, Ryan J. ;

Wiesmann, Christian .

EMBO JOURNAL, 2007, 26 (23) :4902-4912

[10] A novel one pot synthesis of super stable silver nanoparticles using natural plant exudate from azadirachta indica (Neem Gum) and their inimical effect on pathogenic microorganisms [J].

Pandey, S., 1600, American Scientific Publishers (07) :296-299

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