Two Blautia Species Associated with Visceral Fat Accumulation: A One-Year Longitudinal Study

被引：29

作者：

Ozato, Naoki ^{[1
,2
]}

Yamaguchi, Tohru ^{[2
]}

Mori, Kenta ^{[1
,2
]}

Katashima, Mitsuhiro ^{[1
,2
]}

Kumagai, Mika ^{[1
]}

Murashita, Koichi ^{[3
]}

Katsuragi, Yoshihisa ^{[1
,2
]}

Tamada, Yoshinori ^{[4
]}

Kakuta, Masanori ^{[5
,6
]}

Imoto, Seiya ^{[5
]}

Ihara, Kazushige ^{[7
]}

Nakaji, Shigeyuki ^{[7
]}

机构：

[1] Hirosaki Univ, Grad Sch Med, Dept Act Life Promot Sci, Hirosaki, Aomori 0368562, Japan

[2] Kao Corp, Hlth & Wellness Prod Res Labs, Tokyo 1318501, Japan

[3] Hirosaki Univ, Grad Sch Med, COI Res Initiat Org, Hirosaki, Aomori 0368562, Japan

[4] Hirosaki Univ, Innovat Ctr Hlth Promot, Hirosaki, Aomori 0368562, Japan

[5] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Tokyo 1138654, Japan

[6] Tokyo Med & Dent Univ, M&D Data Sci Ctr, Tokyo 1138510, Japan

[7] Hirosaki Univ, Grad Sch Med, Dept Social Med, Hirosaki, Aomori 0368562, Japan

来源：

BIOLOGY-BASEL | 2022年 / 11卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

visceral fat; body mass index; intestinal microflora; obesity; cardiovascular disorder; Blautia hansenii; Blautia producta; ALL-CAUSE MORTALITY; GUT MICROBIOME; INTESTINAL MICROBIOTA; OBESITY; JAPANESE; DIET; WEIGHT; ACIDS; MICE;

D O I：

10.3390/biology11020318

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Simple Summary Intestinal microflora has been associated with obesity. While cardiovascular disorders are more strongly associated with visceral fat than the body mass index (BMI), the link between visceral fat area (VFA) and intestinal microflora has been little studied. In this study, we investigated the association between intestinal microflora and VFA and BMI using a longitudinal study (N = 767). We found that the intestinal microflora composition is significantly associated with VFA or BMI; however, the associated gut microbes differ. Furthermore, two gut species-Blautia hansenii and Blautia producta-were significantly and negatively associated with VFA accumulation. Intestinal microflora has been associated with obesity. While visceral fat is more strongly associated with cardiovascular disorder, a complication linked to obesity, than the body mass index (BMI), the association between intestinal microflora and obesity (as defined in terms of BMI) has been studied widely. However, the link between visceral fat area (VFA) and intestinal microflora has been little studied. In this study, we investigate the association between intestinal microflora and VFA and BMI using a longitudinal study on Japanese subjects with different VFA statuses (N = 767). Principal component analysis of the changes in intestinal microflora composition over the one-year study period revealed the different associations between intestinal microflora and VFA and BMI. As determined by 16S rRNA amplicon sequencing, changes in the abundance ratio of two microbial genera-Blautia and Flavonifractor-were significantly associated with VFA changes and changes in the abundance ratio of four different microbial genera were significantly associated with BMI changes, suggesting that the associated intestinal microbes are different. Furthermore, as determined by metagenomic shotgun sequences, changes in the abundance ratios of two Blautia species-Blautia hansenii and Blautia producta-were significantly and negatively associated with VFA changes. Our findings might be used to develop a new treatment for visceral fat.

引用

页数：16

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