Hybrid Nanocrystals: Achieving Concurrent Therapeutic and Bioimaging Functionalities toward Solid Tumors

被引：59

作者：

Zhao, Rongsheng ^{[1
]}

Hollis, Christin P. ^{[1
]}

Zhang, Hua ^{[1
]}

Sun, Lili ^{[1
]}

Gemeinhart, Richard A. ^{[2
]}

Li, Tonglei ^{[1
]}

机构：

[1] Univ Kentucky, Lexington, KY 40536 USA

[2] Univ Illinois, Chicago, IL 60612 USA

来源：

MOLECULAR PHARMACEUTICS | 2011年 / 8卷 / 05期

关键词：

nanocrystals; anticancer; bioimaging; theranostics; paclitaxel; DRUG-DELIVERY; NANOPARTICLES; TECHNOLOGY; ANTITUMOR;

D O I：

10.1021/mp200154k

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Bioimaging and therapeutic agents accumulated in ectopic tumors following intravenous administration of hybrid nanocrystals to tumor-bearing mice. Solid, nanosized paclitaxel crystals physically incorporated fluorescent molecules throughout the crystal lattice and retained fluorescent properties in the solid state. Hybrid nanocrystals were significantly localized in solid tumors and remained in the tumor for several days. An anticancer effect is expected of these hybrid nanocrystals.

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收藏

页码：1985 / 1991

页数：7

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