Children and Youth Who Use Cannabis for Pain Relief: Benefits, Risks, and Perceptions

被引:12
作者
Woo, Julia J. [1 ]
van Reekum, Emma A. [2 ]
Rosic, Tea [3 ]
Samaan, Zainab [3 ]
机构
[1] Univ Toronto, Fac Med, Toronto, ON, Canada
[2] McMaster Univ, Fac Med, Hamilton, ON, Canada
[3] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada
关键词
marijuana; THC; CBD; adolescents; pediatrics; MARIJUANA USE; MEDICAL MARIJUANA; NEUROPATHIC PAIN; CB1; RECEPTOR; HIGH-POTENCY; DRUG-USE; METAANALYSIS; SCHIZOPHRENIA; ASSOCIATION; OPTION;
D O I
10.2147/AHMT.S254264
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
We provide up-to-date perspectives on the benefits and risks of medical cannabis for pain management in children and youth. To date, only two studies (a case report and a small observational study) have examined the effects of medical cannabis on pain in children and youth. No controlled trial has commented on long-term safety of medical cannabis. Findings from the recreational cannabis literature reveal significant potential short- and long-term risks of regular cannabis use, including impaired driving, depression, suicidality, psychosis, and tolerance. Despite this, many children and youth are self-medicating with cannabis, and perceive regular cannabis use to be safe. There is a need for better education and counselling of patients regarding the benefits and risks of medical cannabis use.
引用
收藏
页码:53 / 61
页数:9
相关论文
共 66 条
[11]   Adolescents' Use of Medical Marijuana: A Secondary Analysis of Monitoring the Future Data [J].
Boyd, Carol J. ;
Veliz, Philip T. ;
McCabe, Sean Esteban .
JOURNAL OF ADOLESCENT HEALTH, 2015, 57 (02) :241-244
[12]   Potential Adverse Drug Events with Tetrahydrocannabinol (THC) Due to Drug-Drug Interactions [J].
Brown, Joshua D. .
JOURNAL OF CLINICAL MEDICINE, 2020, 9 (04)
[13]   Cannabis use and the development of tolerance: a systematic review of human evidence [J].
Colizzi, Marco ;
Bhattacharyya, Sagnik .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2018, 93 :1-25
[14]  
Collins C, 2014, NEW ENGL J MED, V371, P879, DOI [10.1056/NEJMra1402309, 10.1056/NEJMc1407928]
[15]   Paranoid Schizophrenia is Characterized by Increased CB1 Receptor Binding in the Dorsolateral Prefrontal Cortex [J].
Dalton, Victoria S. ;
Long, Leonora E. ;
Weickert, Cyndi Shannon ;
Zavitsanou, Katerina .
NEUROPSYCHOPHARMACOLOGY, 2011, 36 (08) :1620-1630
[16]   High-potency cannabis and the risk of psychosis [J].
Di Forti, Marta ;
Morgan, Craig ;
Dazzan, Paola ;
Pariante, Carmine ;
Mondelli, Valeria ;
Marques, Tiago Reis ;
Handley, Rowena ;
Luzi, Sonija ;
Russo, Manuela ;
Paparelli, Alessandra ;
Butt, Alexander ;
Stilo, Simona A. ;
Wiffen, Ben ;
Powell, John ;
Murray, Robin M. .
BRITISH JOURNAL OF PSYCHIATRY, 2009, 195 (06) :488-491
[17]   Risk of road accident associated with the use of drugs: A systematic review and meta-analysis of evidence from epidemiological studies [J].
Elvik, Rune .
ACCIDENT ANALYSIS AND PREVENTION, 2013, 60 :254-267
[18]   Illicit drug use and prescription drug misuse among young adult medical cannabis patients and non-patient users in Los Angeles [J].
Fedorova, Ekaterina V. ;
Schrager, Sheree M. ;
Robinson, Lucy F. ;
Cepeda, Alice ;
Wong, Carolyn F. ;
Iverson, Ellen ;
Lankenau, Stephen E. .
DRUG AND ALCOHOL DEPENDENCE, 2019, 198 :21-27
[19]   Milk intake and survival in newborn cannabinoid CB1 receptor knockout mice:: evidence for a "CB3" receptor [J].
Fride, E ;
Foox, A ;
Rosenberg, E ;
Faigenboim, M ;
Cohen, V ;
Barda, L ;
Blau, H ;
Mechoulam, R .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 461 (01) :27-34
[20]   Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood A Systematic Review and Meta-analysis [J].
Gobbi, Gabriella ;
Atkin, Tobias ;
Zytynski, Tomasz ;
Wang, Shouao ;
Askari, Sorayya ;
Boruff, Jill ;
Ware, Mark ;
Marmorstein, Naomi ;
Cipriani, Andrea ;
Dendukuri, Nandini ;
Mayo, Nancy .
JAMA PSYCHIATRY, 2019, 76 (04) :426-434