Decreased serum brain-derived neurotrophic factor in trained men

被引：79

作者：

Nofuji, Yu ^{[1
]}

Suwa, Masataka ^{[2
]}

Moriyama, Yoshihiko ^{[1
]}

Nakano, Hiroshi ^{[3
]}

Ichimiya, Atsushi ^{[2
]}

Nishichi, Reiko ^{[4
]}

Sasaki, Haruka ^{[2
]}

Radak, Zsolt ^{[5
]}

Kumagai, Shuzo ^{[2
]}

机构：

[1] Kyushu Univ, Grad Sch Human Environm Studies, Fukuoka 8168580, Japan

[2] Kyushu Univ, Inst Hlth Sci, Fukuoka 8168580, Japan

[3] Nakamura Gakuen Univ, Dept Human Dev, Fukuoka 8140198, Japan

[4] St Marys Univ, Dept Nursing, Fukuoka 8308558, Japan

[5] Semmelweis Univ, Fac Phys Educ & Sports Sci, H-1123 Budapest, Hungary

来源：

NEUROSCIENCE LETTERS | 2008年 / 437卷 / 01期

关键词：

brain-derived neurotrophic factor; physical activity; energy expenditure;

D O I：

10.1016/j.neulet.2008.03.057

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The purpose of this study was to clarify the effect of physical activity on the level of serum brain-derived neurotrophic factor (BDNF). The serum BDNF level in trained men who have participated in regular sport activity (n = 12) was compared to that in sedentary subjects (n = 14). The physical activity levels expressed as total energy expenditure, move-related energy expenditure and walking count in the trained were significantly higher than those in the sedentary. The serum BDNF level in the trained men was found to be lower than that in the sedentary (19.54 +/- 4.53 ng/ml vs. 23.63 +/- 2.94 ng/ml, respectively, P < 0.01). The serum BDNF level showed a significant negative correlation with daily total energy expenditure (r = -0.507, P < 0.05), movement-related energy expenditure (r = -0.503, P < 0.05), and walking count (r = -0.480, P < 0.05). These results may suggest that vigorous habitual physical activity decrease the serum BDNF level. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：29 / 32

页数：4

共 37 条

[31] Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay [J].

Radka, SF ;

Holst, PA ;

Fritsche, M ;

Altar, CA .

BRAIN RESEARCH, 1996, 709 (01) :122-130

[32] Lifecorder: A new device for the long-term monitoring of motor activities for Parkinson's disease [J].

Saito, N ;

Yamamoto, T ;

Sugiura, Y ;

Shimizu, S ;

Shimizu, M .

INTERNAL MEDICINE, 2004, 43 (08) :685-692

[33] Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants [J].

Shimizu, E ;

Hashimoto, K ;

Okamura, N ;

Koike, K ;

Komatsu, N ;

Kumakiri, C ;

Nakazato, M ;

Watanabe, H ;

Shinoda, N ;

Okada, S ;

Iyo, M .

BIOLOGICAL PSYCHIATRY, 2003, 54 (01) :70-75

[34] Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus [J].

Suwa, M ;

Kishimoto, H ;

Nofuji, Y ;

Nakano, H ;

Sasaki, H ;

Radak, Z ;

Kumagai, S .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2006, 55 (07) :852-857

[35] NEUROTROPHINS AND NEURONAL PLASTICITY [J].

THOENEN, H .

SCIENCE, 1995, 270 (5236) :593-598

[36] Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans [J].

Vega, Sandra Rojas ;

Strueder, Heiko K. ;

Wahrmann, Bertha Vera ;

Schmidt, Annette ;

Bloch, Wilhelm ;

Hollmann, Wildor .

BRAIN RESEARCH, 2006, 1121 :59-65

[37] Serum neurotrophins -: A study on the time course and influencing factors in a large old age sample [J].

Ziegenhorn, Andreas A. ;

Schulte-Herbrueggen, Olaf ;

Danker-Hopfe, Heidi ;

Malbranc, Monique ;

Hartung, Heinz-Dieter ;

Anders, Dirk ;

Lang, Undine E. ;

Steinhagen-Thiessen, Elisabeth ;

Schaub, Rainer T. ;

Hellweg, Rainer .

NEUROBIOLOGY OF AGING, 2007, 28 (09) :1436-1445

← 1 2 3 4 →