Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer

被引：59

作者：

Fendler, Annika ^{[1
]}

Shepherd, Scott T. C. ^{[1
,14
,15
]}

Au, Lewis ^{[1
,14
,15
]}

Wu, Mary ^{[2
]}

Harvey, Ruth ^{[3
]}

Schmitt, Andreas M. ^{[14
,15
]}

Tippu, Zayd ^{[1
,14
,15
]}

Shum, Benjamin ^{[1
,14
,15
]}

Farag, Sheima ^{[14
,15
]}

Rogiers, Aljosja ^{[14
,15
]}

Carlyle, Eleanor ^{[14
,15
]}

Edmonds, Kim ^{[14
,15
]}

Del Rosario, Lyra ^{[14
,15
]}

Lingard, Karla ^{[14
,15
]}

Mangwende, Mary ^{[14
,15
]}

Holt, Lucy ^{[14
,15
]}

Ahmod, Hamid ^{[14
,15
]}

Korteweg, Justine ^{[14
,15
]}

Foley, Tara ^{[14
,15
]}

Barber, Taja ^{[1
]}

Emslie-Henry, Andrea ^{[1
]}

Caulfield-Lynch, Niamh ^{[1
]}

Byrne, Fiona ^{[1
]}

Deng, Daqi ^{[1
]}

Kjaer, Svend ^{[4
]}

Song, Ok-Ryul ^{[2
]}

Queval, Christophe ^{[2
]}

Kavanagh, Caitlin ^{[2
]}

Wall, Emma C. ^{[2
,23
]}

Carr, Edward J. ^{[5
]}

Caidan, Simon ^{[6
]}

Gavrielides, Mike ^{[7
]}

MacRae, James I. ^{[8
]}

Kelly, Gavin ^{[9
]}

Peat, Kema ^{[14
,15
]}

Kelly, Denise ^{[14
,15
]}

Murra, Aida ^{[14
,15
]}

Kelly, Kayleigh ^{[14
,15
]}

O'Flaherty, Molly ^{[14
,15
]}

Shea, Robyn L. ^{[16
,24
]}

Gardner, Gail ^{[16
]}

Murray, Darren ^{[16
]}

Yousaf, Nadia ^{[17
,18
]}

Jhanji, Shaman ^{[19
]}

Tatham, Kate ^{[19
]}

Cunningham, David ^{[20
]}

Van As, Nicholas ^{[21
]}

Young, Kate ^{[14
,15
]}

Furness, Andrew J. S. ^{[14
,15
]}

Pickering, Lisa ^{[14
,15
]}

机构：

[1] Francis Crick Inst, Canc Dynam Lab, London NW1 1AT, England

[2] Francis Crick Inst, High Throughput Screening Lab, London NW1 1AT, England

[3] Francis Crick Inst, Worldwide Influenza Ctr, London NW1 1AT, England

[4] Francis Crick Inst, Struct Biol Sci Technol Platform, London NW1 1AT, England

[5] Francis Crick Inst, Cell Biol Infect Lab, London NW1 1AT, England

[6] Francis Crick Inst, Safety Hlth & Sustainabil, London NW1 1AT, England

[7] Francis Crick Inst, Sci Comp Sci Technol Platform, London NW1 1AT, England

[8] Francis Crick Inst, Metabol Sci Technol Platform, London NW1 1AT, England

[9] Francis Crick Inst, Dept Bioinformat & Biostat, London NW1 1AT, England

[10] Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London NW1 1AT, England

[11] Francis Crick Inst, Neurodegenerat Biol Lab, London NW1 1AT, England

[12] Francis Crick Inst, Struct Biol Dis Processes Lab, London NW1 1AT, England

[13] Francis Crick Inst, RNA Virus Replicat Lab, London NW1 1AT, England

[14] Royal Marsden NHS Fdn Trust, Skin Unit, London, England

[15] Royal Marsden NHS Fdn Trust, Renal Unit, London, England

[16] Royal Marsden NHS Fdn Trust, Dept Pathol, London, England

[17] Royal Marsden NHS Fdn Trust, Lung Unit, London, England

[18] Royal Marsden NHS Fdn Trust, Acute Oncol Serv, London, England

[19] Royal Marsden NHS Fdn Trust, Anaesthet Perioperat Med & Pain Dept, London, England

[20] Royal Marsden NHS Fdn Trust, Gastrointestinal Unit, London, England

[21] Royal Marsden NHS Fdn Trust, Clincal Oncol Unit, London, England

[22] Royal Marsden NHS Fdn Trust, Haematooncol Unit, London, England

[23] Univ Coll London Hosp NHS Fdn Trust, Biomed Res Ctr, London, England

[24] Inst Canc Res, Translat Canc Biochem Lab, London, England

[25] Inst Canc Res, Melanoma & Kidney Canc Team, London, England

[26] UCL, Div Med, London, England

[27] UCL, Inst Canc, London, England

[28] UCL Queen Sq Inst Neurol, London, England

来源：

LANCET | 2022年 / 399卷 / 10328期

关键词：

D O I：

10.1016/S0140-6736(22)00147-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：905 / 907

页数：3

共 13 条

[1] Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization
Cele, Sandile
Jackson, Laurelle
Khoury, David S.
Khan, Khadija
Moyo-Gwete, Thandeka
Tegally, Houriiyah
San, James Emmanuel
Cromer, Deborah
Scheepers, Cathrine
Amoako, Daniel G.
Karim, Farina
Bernstein, Mallory
Lustig, Gila
Archary, Derseree
Smith, Muneerah
Ganga, Yashica
Jule, Zesuliwe
Reedoy, Kajal
Hwa, Shi-Hsia
Giandhari, Jennifer
Blackburn, Jonathan M.
Gosnell, Bernadett, I
Karim, Salim S. Abdool
Hanekom, Willem
von Gottberg, Anne
Bhiman, Jinal N.
Lessells, Richard J.
Moosa, Mahomed-Yunus S.
Davenport, Miles P.
de Oliveira, Tulio
Moore, Penny L.
Sigal, Alex
[J]. NATURE, 2022, 602 (7898) : 654 - +
[2] Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis
Cromer, Deborah
Steain, Megan
Reynaldi, Arnold
Schlub, Timothy E.
Wheatley, Adam K.
Juno, Jennifer A.
Kent, Stephen J.
Triccas, James A.
Khoury, David S.
Davenport, Miles P.
[J]. LANCET MICROBE, 2022, 3 (01): : E52 - E61
[3] Immune responses following third COVID-19 vaccination are reduced in patients with hematological compared to patients with solid cancer
Fendler, Annika
Shepherd, Scott T. C.
Au, Lewis
Wilkinson, Katalin A.
Wu, Mary
Schmitt, Andreas M.
Tippu, Zayd
Farag, Sheima
Rogiers, Aljosja
Harvey, Ruth
Carlyle, Eleanor
Edmonds, Kim
Del Rosario, Lyra
Lingard, Karla
Mangwende, Mary
Holt, Lucy
Ahmod, Hamid
Korteweg, Justine
Foley, Tara
Barber, Taja
Emslie-Henry, Andrea
Caulfield-Lynch, Niamh
Byrne, Fiona
Shum, Benjamin
Gerard, Camille L.
Deng, Daqi
Kjaer, Svend
Song, Ok-Ryul
Queval, Christophe
Kavanagh, Caitlin
Wall, Emma C.
Carr, Edward J.
Namjou, Sina
Caidan, Simon
Gavrielides, Mike
MacRae, James I.
Kelly, Gavin
Peat, Kema
Kelly, Denise
Murra, Aida
Kelly, Kayleigh
O'Flaherty, Molly
Shea, Robyn L.
Gardner, Gail
Murray, Darren
Yousaf, Nadia
Jhanji, Shaman
Van As, Nicholas
Young, Kate
Furness, Andrew J. S.
[J]. CANCER CELL, 2022, 40 (02) : 114 - 116
[4] Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study
Fendler, Annika
Shepherd, Scott T. C.
Au, Lewis
Wilkinson, Katalin A.
Wu, Mary
Byrne, Fiona
Cerrone, Maddalena
Schmitt, Andreas M.
Joharatnam-Hogan, Nalinie
Shum, Benjamin
Tippu, Zayd
Rzeniewicz, Karolina
Boos, Laura Amanda
Harvey, Ruth
Carlyle, Eleanor
Edmonds, Kim
Del Rosario, Lyra
Sarker, Sarah
Lingard, Karla
Mangwende, Mary
Holt, Lucy
Ahmod, Hamid
Korteweg, Justine
Foley, Tara
Bazin, Jessica
Gordon, William
Barber, Taja
Emslie-Henry, Andrea
Xie, Wenyi
Gerard, Camille L.
Deng, Daqi
Wall, Emma C.
Agua-Doce, Ana
Namjou, Sina
Caidan, Simon
Gavrielides, Mike
MacRae, James, I
Kelly, Gavin
Peat, Kema
Kelly, Denise
Murra, Aida
Kelly, Kayleigh
O'Flaherty, Molly
Dowdie, Lauren
Ash, Natalie
Gronthoud, Firza
Shea, Robyn L.
Gardner, Gail
Murray, Darren
Kinnaird, Fiona
[J]. NATURE CANCER, 2021, 2 (12) : 1305 - 1320
[5] Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant
Gao, Yu
Cai, Curtis
Grifoni, Alba
Muller, Thomas R.
Niessl, Julia
Olofsson, Anna
Humbert, Marion
Hansson, Lotta
Osterborg, Anders
Bergman, Peter
Chen, Puran
Olsson, Annika
Sandberg, Johan K.
Weiskopf, Daniela
Price, David A.
Ljunggren, Hans-Gustaf
Karlsson, Annika C.
Sette, Alessandro
Aleman, Soo
Buggert, Marcus
[J]. NATURE MEDICINE, 2022, 28 (03) : 472 - +
[6] GeurtsvanKessel C.H., 2021, MEDRXIV2021220220211, DOI 10.1101/2021.12.27.21268416
[7] Gruell H., 2021, mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant, DOI DOI 10.1101/2021.12.14.21267769
[8] Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection
Khoury, David S.
Cromer, Deborah
Reynaldi, Arnold
Schlub, Timothy E.
Wheatley, Adam K.
Juno, Jennifer A.
Subbarao, Kanta
Kent, Stephen J.
Triccas, James A.
Davenport, Miles P.
[J]. NATURE MEDICINE, 2021, 27 (07) : 1205 - +
[9] Third BNT162b2 Vaccination Neutralization of SARS-CoV-2 Omicron Infection
Nemet, Ital
Kliker, Limor
Lustig, Yaniv
Zuckerman, Neta
Erster, Oran
Cohen, Carmit
Kreiss, Yitshak
Alroy-Preis, Sharon
Regev-Yochay, Gili
Mendelson, Ella
Mandelboim, Michal
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (05) : 492 - 494
[10] COVID-19 vaccination and breakthrough infections in patients with cancer
Schmidt, A. L.
Labaki, C.
Hsu, C-Y
Bakouny, Z.
Balanchivadze, N.
Berg, S. A.
Blau, S.
Daher, A.
El Zarif, T.
Friese, C. R.
Griffiths, E. A.
Hawley, J. E.
Hayes-Lattin, B.
Karivedu, V
Latif, T.
Mavromatis, B. H.
McKay, R. R.
Nagaraj, G.
Nguyen, R. H.
Panagiotou, O. A.
Portuguese, A. J.
Puc, M.
Dutra, M. Santos
Schroeder, B. A.
Thakkar, A.
Wulff-Burchfield, E. M.
Mishra, S.
Farmakiotis, D.
Shyr, Yu
Warner, J. L.
Choueiri, T. K.
[J]. ANNALS OF ONCOLOGY, 2022, 33 (03) : 340 - 346

← 1 2 →