Serum macrophage migration inhibitory factor in the prediction of preterm delivery

被引：37

作者：

Pearce, Brad D. ^{[1
,2
]}

Garvin, Sicily E. ^{[1
]}

Grove, Jakob ^{[3
]}

Bonney, Elizabeth A. ^{[4
]}

Dudley, Donald J. ^{[5
]}

Schendel, Diana E. ^{[6
]}

Thorsen, Poul ^{[3
]}

机构：

[1] Emory Univ, Dept Psychol, Atlanta, GA 30332 USA

[2] Emory Univ, Grad Div Biol & Biomed Sci, Atlanta, GA 30332 USA

[3] Univ Aarhus, Inst Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[4] Univ Vermont, Dept Obstet & Gynecol, Burlington, VT USA

[5] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, San Antonio, TX 78229 USA

[6] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2008年 / 199卷 / 01期

关键词：

cortisol; cytokine; macrophage migration inhibitory factor; pregnancy; preterm birth;

D O I：

10.1016/j.ajog.2007.11.066

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: Macrophage migration inhibitory factor is a soluble mediator that helps govern the interaction between cytokines and stress hormones (eg, cortisol). We determined whether maternal macrophage migration inhibitory factor levels predicted subsequent preterm delivery. STUDY DESIGN: A nested case-control study measuring serum macrophage migration inhibitory factor concentration at 9-23 weeks' gestation in women who ultimately delivered preterm (n = 60) compared with control women who delivered at term (n = 122). We also examined the connection of macrophage migration inhibitory factor with self-reported psychosocial variables. RESULTS: Macrophage migration inhibitory factor was elevated in the preterm delivery cases (P = .0004), and log macrophage migration inhibitory factor concentration showed a graded response relationship with likelihood of preterm delivery. High-macrophage migration inhibitory factor was also associated with maternal risk-taking behavior, which itself was a risk factor for preterm delivery. Macrophage migration inhibitory factor remained associated independently with preterm delivery after adjusting regression models for several other preterm delivery risk factors (odds ratio, 3.11, 95% confidence interval, 1.54-6.30). CONCLUSION: High-serum macrophage migration inhibitory concentration in early to midpregnancy is linked with subsequent preterm delivery.

引用

页码：46.e1 / 46.e6

页数：6

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