Antibody profiling in plague patients by protein microarray

被引：24

作者：

Li, Bei ^{[1
]}

Zhou, Dongsheng ^{[1
]}

Wang, Zuyun ^{[2
]}

Song, Zhizhong ^{[3
]}

Wang, Hu ^{[2
]}

Li, Min ^{[2
]}

Dong, Xingqi ^{[3
]}

Wu, Mingshou ^{[3
]}

Guo, Zhaobiao ^{[1
]}

Yang, Ruifu ^{[1
]}

机构：

[1] Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Lab Analyt Microbiol, Beijing 100071, Peoples R China

[2] Qinghai Inst Endem Dis Prevent & Control, Xining, Qinghai Prov, Peoples R China

[3] Yunnan Inst Epidem Dis Control & Res, Dali, Yunnan Prov, Peoples R China

来源：

MICROBES AND INFECTION | 2008年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

protein microarray; yersinia pestis; antibody profile;

D O I：

10.1016/j.micinf.2007.10.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A protein microarray containing 144 known or putative virulence-related proteins of Yersinia pestis was used to evaluate the antibody responses of plague patients. Forty-two proteins were found to be expressed in vivo and antibodies against 14 of them were detected in all patients analyzed, providing potential candidates for novel protective antigens and novel serodiagnostic markers in Y. pestis. Moreover, the lack of antibody to LcrV in the five patients in Focus F might be a challenge to our understanding of the pathogenesis of Y. pestis. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：45 / 51

页数：7

共 30 条

[1]

Bacarese-Hamilton Tito, 2004, Methods Mol Biol, V264, P271

[2]

Benner GE, 1999, INFECT IMMUN, V67, P1922

[3] Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis [J].

Chain, PSG ;

Carniel, E ;

Larimer, FW ;

Lamerdin, J ;

Stoutland, PO ;

Regala, WM ;

Georgescu, AM ;

Vergez, LM ;

Land, ML ;

Motin, VL ;

Brubaker, RR ;

Fowler, J ;

Hinnebusch, J ;

Marceau, M ;

Medigue, C ;

Simonet, M ;

Chenal-Francisque, V ;

Souza, B ;

Dacheux, D ;

Elliott, JM ;

Derbise, A ;

Hauser, LJ ;

Garcia, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (38) :13826-13831

[4] Antigenicity analysis of different regions of the severe acute respiratory syndrome coronavirus nucleocapsid protein [J].

Chen, ZL ;

Pei, DC ;

Jiang, LX ;

Song, YJ ;

Wang, J ;

Wang, HX ;

Zhou, DS ;

Zhai, JH ;

Du, ZM ;

Li, B ;

Qiu, MF ;

Han, YP ;

Guo, ZB ;

Yang, RF .

CLINICAL CHEMISTRY, 2004, 50 (06) :988-995

[5] Molecular and cell biology aspects of plague [J].

Cornelis, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) :8778-8783

[6]

Grosfeld H, 2003, ADV EXP MED BIOL, V529, P423

[7] Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis [J].

Guiyoule, A ;

Gerbaud, G ;

Buchrieser, C ;

Galimand, M ;

Rahalison, L ;

Chanteau, S ;

Courvalin, P ;

Carniel, E .

EMERGING INFECTIOUS DISEASES, 2001, 7 (01) :43-48

[8] Plague as a biological weapon - Medical and public health management [J].

Inglesby, TV ;

Dennis, DT ;

Henderson, DA ;

Bartlett, JG ;

Ascher, MS ;

Eitzen, E ;

Fine, AD ;

Friedlander, AM ;

Hauer, J ;

Koerner, JF ;

Layton, M ;

McDade, J ;

Osterholm, MT ;

O'Toole, T ;

Parker, G ;

Perl, TM ;

Russell, PK ;

Schoch-Spana, M ;

Tonat, K .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (17) :2281-2290

[9]

Ji S, 1990, CHI J EPIDEMIOL, V11, P1

[10] Yersinia outer proteins (YOPS) E, K and N are antigenic but non-protective compared to V antigen, in a murine model of bubonic plague [J].

Leary, SEC ;

Griffin, KF ;

Galyov, EE ;

Hewer, J ;

Williamson, ED ;

Holmström, A ;

Forsberg, Å ;

Titball, RW .

MICROBIAL PATHOGENESIS, 1999, 26 (03) :159-169

← 1 2 3 →