Synthesis and antitumour activity of pyrene-linked pyrrolo [2,1-c][1,4]benzodiazepine hybrids

被引：54

作者：

Kamal, A ^{[1
]}

Ramesh, G ^{[1
]}

Srinivas, O ^{[1
]}

Ramulu, P ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 02期

关键词：

pyrrolobenzodiazepines; pyrene amine; cytotoxity; DNA-binding affinity;

D O I：

10.1016/j.bmcl.2003.10.050

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pyrene-linked pyrrolobenzodiazepine hybrids have been synthesized that exhibit potential anticancer activity in a number of human tumour cell lines. These hybrids also exhibit much enhanced DNA-binding ability in comparison to the parent pyrrolobenzodiazepine ring system (DC-81). (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：471 / 474

页数：4

共 23 条

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