Interaction of three new tetradentates Schiff bases containing N2O2 donor atoms with calf thymus DNA

被引：15

作者：

Ajloo, Davood ^{[1
]}

Shabanpanah, Sajede ^{[1
]}

Shafaatian, Bita ^{[1
]}

Ghadamgahi, Maryam ^{[1
]}

Alipour, Yasin ^{[1
]}

Lashgarbolouki, Taghi ^{[2
]}

Saboury, Ali Akbar ^{[3
]}

机构：

[1] Damghan Univ, Sch Chem, Damghan, Iran

[2] Damghan Univ, Sch Biol, Damghan, Iran

[3] Univ Tehran, Inst Biochem & Biophys, Tehran, Iran

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2015年 / 77卷

关键词：

Calf-thymus DNA; Schiff-base; Spectroscopy; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURES; BINDING; LIGAND; DAMAGE;

D O I：

10.1016/j.ijbiomac.2015.03.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interaction of 1,3-bis(2-hydroxy-benzylidene)-urea (H2L1), 1,3-bis(2-hydroxy-3-methoxy-benzylidene)-urea (H2L2) and 1,3-bis(2-hydroxy-3-methoxy-benzylidene)-urea nickel(II) (NiL2) with calf-thymus DNA were investigated by UV-vis absorption, fluorescence emission and circular dichroism (CD) spectroscopy as well as cyclic voltammetry, viscosity measurements, molecular docking and molecular dynamics simulation. Binding constants were determined using UV-vis absorption and fluorescence spectra. The results indicated that studied Schiff-bases bind to DNA in the intercalative mode in which the metal derivative is more effective than non metals. Their interaction trend is further determined by molecular dynamics (MD) simulation. MD results showed that Ni derivative reduces oligonucleotide intermolecular hydrogen bond and increases solvent accessible surface area more than other compounds. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：193 / 202

页数：10

共 52 条

[1] Intercalation of antitumor drug doxorubicin and its analogue by DNA duplex: Structural features and biological implications [J].