The application of microspheres from the copolymers of lactide and ε-caprolactone to the controlled release of steroids

被引：50

作者：

Buntner, B

Nowak, M

Kasperczyk, J ^{[1
]}

Ryba, M

Grieb, P

Walski, M

Dobrzyñski, P

Bero, M

机构：

[1] Silesain Ctr Cardiol, PL-40635 Katowice, Poland

[2] Silesian Univ, Sch Med, Dept Pathophysiol, PL-41800 Zabrze, Poland

[3] Polish Acad Sci, Med Res Ctr, PL-02106 Warsaw, Poland

[4] Polish Acad Sci, Inst Polymer Chem, PL-41800 Zabrze, Poland

来源：

JOURNAL OF CONTROLLED RELEASE | 1998年 / 56卷 / 1-3期

关键词：

poly(D; L-lactide-co-epsilon-caprolactone); microspheres; progesterone; beta-estradiol; microencapsulation; controlled drug delivery;

D O I：

10.1016/S0168-3659(98)00085-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The microspheres made of the copolymers of lactide and epsilon-caprolactone were used for the controlled release of progesterone and beta-estradiol. The copolymers contained 83-94% of L or D,L-lactide. The influence of the microstructure of lactidyl blocks in the copolymer chains on the drug release rate was studied. More uniform release rate was observed in the case of the copolymer derived from D,L-lactide as composed to L-lactide. For the copolymer containing 83-94% of D,L-lactide units the progesterone and beta-estradiol release rate in vitro was found to be practically constant within over 40 days. The in vivo studies performed on rats revealed that the period of constant release rate of beta-estradiol can be prolonged to about 70 days. The microspheres made of the applied poly-(D,L-lactide-co-epsilon-caprolactone) are the convenient system for long time release of steroids. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：159 / 167

页数：9

共 30 条

[1] EFFECT OF TEMPERATURE ON MECHANISMS OF DRUG-RELEASE AND MATRIX DEGRADATION OF POLY(D,L-LACTIDE) MICROSPHERES [J].