Assessment of polyaniline nanoparticles toxicity and teratogenicity in aquatic environment using Rhinella arenarum model

被引：47

作者：

Ibarra, Luis E. ^{[1
]}

Tarres, Lucrecia ^{[1
]}

Bongiovanni, Silvestre ^{[2
]}

Barbero, Cesar A. ^{[2
]}

Kogan, Marcelo J. ^{[3
]}

Rivarola, Viviana A. ^{[1
]}

Bertuzzi, Mabel L. ^{[1
]}

Yslas, Edith I. ^{[1
]}

机构：

[1] Univ Nacl Rio Cuarto, Dept Biol Mol, Agenda Postal 3,X580BYA, Rio Cuarto, Argentina

[2] Univ Nacl Rio Cuarto, Dept Quim, Rio Cuarto, Argentina

[3] Univ Chile, Fac Ciencias Quim & Farmaceut, Santiago, Chile

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2015年 / 114卷

关键词：

Nanoparticles; Teratogenesis; Toxicity test; Stage-dependent susceptibility; Ecotoxicology; DEVELOPMENTAL TOXICITY; OXIDE NANOPARTICLES; POLYMER; ZEBRAFISH; EMBRYOS; FILMS; BIOCOMPATIBILITY; DISPERSIONS; PARTICLES; TADPOLES;

D O I：

10.1016/j.ecoenv.2015.01.013

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

With the rapid growth of nanotechnology and the applications of nanoparticles, environmental exposure to these particles is increasing. However, their impact in human and environmental health is not well studied. Anurans, with life stage comprising embryos, tadpoles and adults, have an extremely permeable skin which makes them excellent indicators of environmental health. This study evaluated the acute toxicity effects of polyaniline nanoparticles (PANI-Np) in different dispersant on embryos and larvae of Rhinella arenarum. The results showed that LC50 of PANI-Np dispersed in polyvinylpyrrolidone (PVP) were 1500 mg/L, while LC50 by PANI-Np dispersed in PVP+PNIPAM (polyN-isopropylacrilamide) showed a highest toxicity (1170 mg/L). The embryo teratogenicity increased with increasing exposure concentration in both kinds of PANI-Np although in PANI-Npl, there is an increased teratogenic effect associated with the polymer stabilizer PVP. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：84 / 92

页数：9

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